rac-tert-butyl 3-(4-hydroxy-2-methylphenyl)-4-oxo-1-piperidinecarboxylate

Base Information

• Chemical Name: rac-tert-butyl 3-(4-hydroxy-2-methylphenyl)-4-oxo-1-piperidinecarboxylate
• CAS No.: 1247091-09-3
• Molecular Formula: C₁₇H₂₃NO₄
• Molecular Weight: 305.374
• Mol file: 1247091-09-3.mol

Synonyms:rac-tert-butyl 3-(4-hydroxy-2-methylphenyl)-4-oxo-1-piperidinecarboxylate

Chemical Property of rac-tert-butyl 3-(4-hydroxy-2-methylphenyl)-4-oxo-1-piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-tert-butyl 3-(4-hydroxy-2-methylphenyl)-4-oxo-1-piperidinecarboxylate

There total 2 articles about rac-tert-butyl 3-(4-hydroxy-2-methylphenyl)-4-oxo-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-3-methylphenyl pivalate (1204517-73-6) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → rac-tert-butyl 3-(4-hydroxy-2-methylphenyl)-4-oxo-1-piperidinecarboxylate (1247091-09-3)

Guidance literature:

With sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis(di-tertbutylphosphino)ferrocene; In tetrahydrofuran; at 70 ℃; for 12h; Inert atmosphere;

Reference yield:

4-bromo-3-methylphenol (14472-14-1) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → rac-tert-butyl 3-(4-hydroxy-2-methylphenyl)-4-oxo-1-piperidinecarboxylate (1247091-09-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; sodium t-butanolate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2012.01.044

Reference yield:

rac-tert-butyl 3-(4-hydroxy-2-methylphenyl)-4-oxo-1-piperidinecarboxylate (1247091-09-3) + tert-butyldimethylsilyl chloride (18162-48-6) → rac-tert-butyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}-2-methylphenyl)-4-oxo-1-piperidinecarboxylate (1307795-73-8)

Guidance literature:

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

upstream raw materials:

4-bromo-3-methylphenyl pivalate

N-tert-butyloxycarbonylpiperidin-4-one

4-bromo-3-methylphenol

Downstream raw materials:

rac-tert-butyl 3-(4-{[tert-butyl(dimethyl)silyl]oxy}-2-methylphenyl)-4-oxo-1-piperidinecarboxylate

tert-butyl (1R,3'S)-3'-[2'-(2-{[(benzyloxy)carbonyl]amino}ethyl)-3-methyl-4-biphenylyl]-5,6-difluoro-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate

tert-butyl (1R,3'S)-3'-[2'-(2-aminoethyl)-3-methyl-4-biphenylyl]-5,6-difluoro-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate

tert-butyl (1R,3'S)-3'-{2'-[2-(acetylamino)ethyl]-3-methyl-4-biphenylyl}-5,6-difluoro-3-oxo-1'H,3H-spiro[2-benzofuran-1,4'-piperidine]-1'-carboxylate