Methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(methylthio)picolinate

Base Information

Chemical Name:Methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(methylthio)picolinate
CAS No.:1417332-25-2
Molecular Formula:C₁₅H₁₃ClF₂N₂O₃S
Molecular Weight:374.796
Hs Code.:

Synonyms:Methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(methylthio)picolinate

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Chemical Property of Methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(methylthio)picolinate

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Technology Process of Methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(methylthio)picolinate

There total 9 articles about Methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(methylthio)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126321-06-9
2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1417331-89-5
Methyl 4-amino-6-chloro-5-fluoro-3-(methylthio)picolinate

: 1417332-25-2
Methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(methylthio)picolinate

Guidance literature:: With cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 115 ℃; for 0.5h; microwave irradiation;

Reference yield:

: 496849-76-4
4,5,6-trichloro-pyridine-2-carboxylic acid methyl ester

: 1417332-25-2
Methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(methylthio)picolinate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 20 h / Dean-Stark apparatus; Reflux

1.2: 20 °C

2.1: cesium fluoride / 3.5 h / 100 - 110 °C / Dean-Stark apparatus; Inert atmosphere

3.1: ammonia / dimethyl sulfoxide / 2 h / 16 °C

4.1: hydrogenchloride / 1,4-dioxane / 20 - 100 °C

5.1: titanium(IV) isopropylate / 4 h / Reflux

6.1: iodine; periodic acid / methanol / 20 h / Reflux

7.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 21 h / 80 °C

8.1: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.5 h / 115 °C / microwave irradiation

With titanium(IV) isopropylate; hydrogenchloride; sulfuric acid; ammonia; iodine; periodic acid; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1388157-65-0
isopropyl 4-amino-6-chloro-5-fluoropicolinate

: 1417332-25-2
Methyl 4-amino-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoro-3-(methylthio)picolinate

Guidance literature:: Multi-step reaction with 4 steps

1: titanium(IV) isopropylate / 4 h / Reflux

2: iodine; periodic acid / methanol / 20 h / Reflux

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 21 h / 80 °C

4: cesium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.5 h / 115 °C / microwave irradiation

With titanium(IV) isopropylate; iodine; periodic acid; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In methanol; water; N,N-dimethyl-formamide; acetonitrile;