1126321-06-9Relevant academic research and scientific papers
ARYL ETHER-BASE KINASE INHIBITORS
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Page/Page column 134, (2015/03/28)
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
ARYL LACTAM KINASE INHIBITORS
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Page/Page column 261, (2015/11/02)
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
Aryl vinyllactam serinekinase inhibitor
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Paragraph 0453, (2016/10/09)
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
Design and application of a low-temperature continuous flow chemistry platform
Newby, James A.,Blaylock, D. Wayne,Witt, Paul M.,Pastre, Julio C.,Zacharova, Marija K.,Ley, Steven V.,Browne, Duncan L.
, p. 1211 - 1220 (2014/12/10)
A flow reactor platform technology applicable to a broad range of low temperature chemistry is reported. The newly developed system captures the essence of running low temperature reactions in batch and represents this as a series of five flow coils, each with independently variable volume. The system was initially applied to the functionalization of alkynes, Grignard addition reactions, heterocycle functionalization, and heteroatom acetylation. This new platform has then been used in the preparation of a 20-compound library of polysubstituted, fluorine-containing aromatic substrates from a sequential metalation-quench procedure and can be readily adapted to provide gaseous electrophile inputs such as carbon dioxide using a tube-in-tube reactor.
Aryl Ether-Base Kinase Inhibitors
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Paragraph 0292, (2013/09/26)
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.
METHODS OF FORMING 4-CHLORO-2-FLUORO-3-SUBSTITUTED-PHENYLBORONIC ACID PINACOL ESTERS AND METHODS OF USING THE SAME
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, (2013/07/19)
Methods include formation of 4-chloro-2 fluoro-3 substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous base to form a (4-chloro-2-fluoro-3-substituted phenyl)trihydroxyborate. The (-chloro-2-fluoro-3-substituted phenyl)trihydroxyborate is reacted with an acid to form a 4-chloro-2-fluoro-3-substituted phenylboronic acid. The 4-chloro-2-fluoro-3-substituted phenylboronic acid is reacted with 2,3 dimethyl 2,3 butanediol to form 4-chloro-2-fluoro-3-substituted phenylboronic acid pinacol esters. Methods of using 4-chloro-2-fluoro-3-substituted phenylboronic acid pinacol esters to produce 6 (4-chloro-2-fluoro-3-substituted phenyl) 4 aminopicolinates are also disclosed.
