2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoic acid hydrochloride

Base Information

Chemical Name:2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoic acid hydrochloride
CAS No.:644970-28-5
Molecular Formula:C₂₃H₂₆FNO₅*ClH
Molecular Weight:451.922
Hs Code.:

Synonyms:2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoic acid hydrochloride

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Chemical Property of 2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoic acid hydrochloride

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Technology Process of 2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoic acid hydrochloride

There total 7 articles about 2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoate

: 644970-28-5
2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoic acid hydrochloride

Guidance literature:: methyl 2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoate; With potassium hydroxide; In ethanol; water; for 5h; Heating / reflux;

With hydrogenchloride; In ethanol; water; at 0 ℃; pH=2;

Reference yield:

: 85117-99-3
2-(bromomethyl)-1,4-difluorobenzene

: 644970-28-5
2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium / iodine / diethyl ether / 1.67 h / Heating / reflux

1.2: 20 °C

1.3: 20 °C

2.1: sodium hydride / toluene / 0.08 h / 110 °C

2.2: 2 h / Heating / reflux

3.1: chloroformic acid ethyl ester / toluene / Heating / reflux

3.2: Heating / reflux

4.1: ethanol / 4.5 h / 85 °C

5.1: potassium hydroxide / ethanol; water / 5 h / Heating / reflux

5.2: 0 °C / pH 2

With potassium hydroxide; chloroformic acid ethyl ester; sodium hydride; magnesium; iodine; In diethyl ether; ethanol; water; toluene;

Reference yield:

: 644967-86-2
5-fluoro-3H-spiro[1-benzofuran-2,4'-piperidine]

: 644970-28-5
2-{[(2S)-3-(5-fluoro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-methylbenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 4.5 h / 85 °C

2.1: potassium hydroxide / ethanol; water / 5 h / Heating / reflux

2.2: 0 °C / pH 2

With potassium hydroxide; In ethanol; water;