4-[(1R,2R)-2-aminocyclohexylamino]-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester hydrochloride

Base Information

• Chemical Name: 4-[(1R,2R)-2-aminocyclohexylamino]-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester hydrochloride
• CAS No.: 914383-31-6
• Molecular Formula: C₁₈H₂₃N₃O₃*ClH
• Molecular Weight: 365.86
• Mol file: 914383-31-6.mol

Synonyms:4-[(1R,2R)-2-aminocyclohexylamino]-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester hydrochloride

Chemical Property of 4-[(1R,2R)-2-aminocyclohexylamino]-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(1R,2R)-2-aminocyclohexylamino]-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester hydrochloride

There total 1 articles about 4-[(1R,2R)-2-aminocyclohexylamino]-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) + 4-hydroxy-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester (182352-44-9) → 4-[(1R,2R)-2-aminocyclohexylamino]-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester hydrochloride (914383-31-6)

Guidance literature:

(1R,2R)-1,2-diaminocyclohexane; 4-hydroxy-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester; In ethanol; ethyl acetate; at 15 - 21 ℃;

With hydrogenchloride; In ethanol; water; ethyl acetate; at 60 ℃; for 3h;

Reference yield:

4-[(1R,2R)-2-aminocyclohexylamino]-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester hydrochloride (914383-31-6) → 4-[(1R,2R)-2-aminocyclohexylamino]-3-pyrroline-2-one hydrochloride (914383-32-7)

Guidance literature:

With hydrogen; 5% palladium over charcoal; In methanol; at 25 ℃; for 3 - 4.5h; Product distribution / selectivity;

upstream raw materials:

(1R,2R)-1,2-diaminocyclohexane

4-hydroxy-2-oxo-3-pyrroline-1-carboxylic acid benzyl ester

Downstream raw materials:

4-[(1R,2R)-2-aminocyclohexylamino]-3-pyrroline-2-one hydrochloride