3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

Base Information

• Chemical Name: 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
• CAS No.: 1061604-41-8
• Molecular Formula: C₁₃H₁₂N₂O₄
• Molecular Weight: 260.249
• Mol file: 1061604-41-8.mol

Synonyms:3-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione

Chemical Property of 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

Chemical Property:

• Boiling Point: 602.9±55.0 °C(Predicted)
• PKA: 8.86±0.20(Predicted)
• Density: 1.498±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Lenalidomide-4-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione

There total 9 articles about 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(4-((tert-butyldimethylsilyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione → 3-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (1061604-41-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

Reference yield: 58.0%

methyl 2-formyl-3-hydroxybenzoate (131524-43-1) + (+/-)-α-aminoglutarimide (2353-44-8,673485-72-8) → 3-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (1061604-41-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In methanol; at 80 ℃; for 12h;

Reference yield: 40.0%

[2‐(2,6‐dioxopiperidin‐3‐yl)‐1‐oxoisoindolin‐4‐yl]boronic acid → 3-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (1061604-41-8)

Guidance literature:

With dihydrogen peroxide; In dimethyl sulfoxide; at 20 ℃; for 8h; Inert atmosphere;

upstream raw materials:

Lenalidomide

methyl 3-hydroxy-2-methylbenzoate

3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-benzoic acid methyl ester

2-bromomethyl-3-(tert-butyl-dimethyl-silanyloxy)-benzoic acid methyl ester

Downstream raw materials:

4-carbamoyl-4-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-butyric acid methyl ester

3-[4-(4-morpholin-4-ylmethyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione

tert-butyl 4-[[4-[[2-(2,6-dioxo-3-piperidyl)-1-oxoisoindolin-4-yl]oxymethyl]phenyl]methyl]piperazine-1-carboxylate

3-(4-(benzyloxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

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