131524-43-1Relevant articles and documents
Total synthesis of neo-tanshinlactones through a cascade benzannulation-lactonization as the key step
Ghosh, Ketaki,Karmakar, Raju,Mal, Dipakranjan
, p. 4037 - 4046 (2013)
The cascade annulation-lactonization of phthalides with α-carboxyfurylacrylates in the presence of lithium hexamethyldisilazide (LiHMDS) provides both convergent and semiconvergent regioselective syntheses of neo-tanshinlactones in moderate yields. This methodology also offers an avenue for the direct syntheses of hitherto unreported 6-alkoxycarbonyl-substituted neo-tanshinlactones and their heterocyclic analogues. A new synthesis of 4-alkyl phthalides was developed on the basis of a combination of a Duff reaction and Fuerstner cross-coupling. The cascade benzannulation-lactonization of phthalides with α-carboxyfurylacrylates was employed as the key reaction for the concise synthesis of neo-tanshinlactone. Copyright
PROCESSES FOR PREPARATION OF (S)-TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE
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Paragraph 00383-00387, (2019/03/12)
Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.
A microwave-assisted domino rearrangement of propargyl vinyl ethers to multifunctionalized aromatic platforms
Tejedor, David,Mendez-Abt, Gabriela,Cotos, Leandro,Ramirez, Miguel A.,Garcia-Tellado, Fernando
supporting information; experimental part, p. 3318 - 3321 (2011/05/02)
H makes a difference! A novel reactivity profile of propargyl vinyl ethers has been developed, which is controlled by the presence of a hydrogen atom at the homopropargylic position (see scheme; EWG=electron-withdrawing group). This strategy was conveniently used to construct multifunctionalized phenolic platforms, including salicylaldehydes and the corresponding ketone derivatives. Copyright