(1E,4E)-2-hydrazinyl-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

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Chemical Name:(1E,4E)-2-hydrazinyl-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide
CAS No.:1384958-35-3
Molecular Formula:C₂₈H₃₅N₅O₂
Molecular Weight:473.618
Hs Code.:

Synonyms:(1E,4E)-2-hydrazinyl-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

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Chemical Property of (1E,4E)-2-hydrazinyl-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

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Technology Process of (1E,4E)-2-hydrazinyl-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

There total 8 articles about (1E,4E)-2-hydrazinyl-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1226791-83-8
(tert-butoxy)-N-{4-(N,N-dipropylcarbamoyl)-8-[4-(pyrrolidinylcarbonyl)phenyl](3H-benzo[f]azepin-2-yl)}carboxamide

: 1384958-35-3
(1E,4E)-2-hydrazinyl-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Guidance literature:: With hydrazine; In ethanol; at 80 ℃; for 0.5h; sealed tube;

Reference yield:

: 389621-81-2
[4-(pyrrolidin-1-ylcarbonyl)phenyl]boronic acid

: 1384958-35-3
(1E,4E)-2-hydrazinyl-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 18 h / 100 °C

2.1: toluene / 2.5 h / Reflux

3.1: acetic acid; iron / 4 h / 20 - 85 °C

3.2: pH 9 - 10

4.1: dichloromethane / 72 h / 20 °C

5.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 30 h / 0 - 20 °C

5.2: pH 3.5

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C

6.2: 1 h / 20 °C

7.1: hydrazine / ethanol / 0.5 h / 80 °C / sealed tube

With iron; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 60956-26-5
4-bromo-2-nitrotoluene

: 1384958-35-3
(1E,4E)-2-hydrazinyl-N,N-dipropyl-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic anhydride; chromium(VI) oxide; sulfuric acid / 1 h / 0 - 10 °C

1.3: 0.75 h

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 18 h / 100 °C

3.1: toluene / 2.5 h / Reflux

4.1: acetic acid; iron / 4 h / 20 - 85 °C

4.2: pH 9 - 10

5.1: dichloromethane / 72 h / 20 °C

6.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 30 h / 0 - 20 °C

6.2: pH 3.5

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C

7.2: 1 h / 20 °C

8.1: hydrazine / ethanol / 0.5 h / 80 °C / sealed tube

With chromium(VI) oxide; sulfuric acid; acetic anhydride; iron; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;