(R)-N-Cbz-3,4-Dihydro-1H-isoquinolinecarboxylic acid

Base Information

• Chemical Name: (R)-N-Cbz-3,4-Dihydro-1H-isoquinolinecarboxylic acid
• CAS No.: 151004-88-5
• Molecular Formula: C18H17NO4
• Molecular Weight: 311.337
• Hs Code.: 2933499090
• Mol file: 151004-88-5.mol

Synonyms:1,2(1H)-Isoquinolinedicarboxylicacid, 3,4-dihydro-, 2-(phenylmethyl) ester, (R)-;

Chemical Property of (R)-N-Cbz-3,4-Dihydro-1H-isoquinolinecarboxylic acid

Chemical Property:

• Vapor Pressure: 1.05E-11mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 521.6 °C at 760 mmHg
• PKA: 3.47±0.20(Predicted)
• Flash Point: 269.2 °C
• PSA: 66.84000
• Density: 1.308 g/cm³
• LogP: 2.94510
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-N-Cbz-3,4-dihydro-1h-isoquinolinecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-N-Cbz-3,4-Dihydro-1H-isoquinolinecarboxylic acid

There total 2 articles about (R)-N-Cbz-3,4-Dihydro-1H-isoquinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(S)-1-((E)-Styryl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester (910632-69-8) → (R)-N-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisiquinoline-1-carboxylic acid (151004-88-5)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃;

DOI:10.1021/ol0614525

Reference yield:

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + (R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (151004-93-2) → (R)-N-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisiquinoline-1-carboxylic acid (151004-88-5)

Guidance literature:

Reference yield: 100.0%

(R)-N-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisiquinoline-1-carboxylic acid (151004-88-5) → N-(benzyloxycarbonyl)-1(R)-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline (832711-65-6)

Guidance literature:

(R)-N-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisiquinoline-1-carboxylic acid; With borane-THF; In tetrahydrofuran; for 3h;

With acetic acid; In tetrahydrofuran; methanol; for 0.5h;

upstream raw materials:

(S)-1-((E)-Styryl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

N-(Benzyloxycarbonyloxy)succinimide

(R)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

Downstream raw materials:

N-(benzyloxycarbonyl)-1(R)-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline

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