4-(2-Cyanophenyl)-4-cyano-N-(3-[N-{1,1-dimethyl ethoxycarbonyl}]amino)propylpiperidine

Base Information

Chemical Name:4-(2-Cyanophenyl)-4-cyano-N-(3-[N-{1,1-dimethyl ethoxycarbonyl}]amino)propylpiperidine
CAS No.:268205-04-5
Molecular Formula:C₂₁H₂₈N₄O₂
Molecular Weight:368.479
Hs Code.:

Synonyms:4-(2-Cyanophenyl)-4-cyano-N-(3-[N-{1,1-dimethyl ethoxycarbonyl}]amino)propylpiperidine

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Chemical Property of 4-(2-Cyanophenyl)-4-cyano-N-(3-[N-{1,1-dimethyl ethoxycarbonyl}]amino)propylpiperidine

Chemical Property:

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Technology Process of 4-(2-Cyanophenyl)-4-cyano-N-(3-[N-{1,1-dimethyl ethoxycarbonyl}]amino)propylpiperidine

There total 8 articles about 4-(2-Cyanophenyl)-4-cyano-N-(3-[N-{1,1-dimethyl ethoxycarbonyl}]amino)propylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 4-cyano-4-(2-cyanophenyl)piperidine hydrochloride

: 1-(3-amino-propyl)-4-cyanophenyl)-piperidine-4-carbonitrile hydrochloride

: 268205-04-5
4-(2-Cyanophenyl)-4-cyano-N-(3-[N-{1,1-dimethyl ethoxycarbonyl}]amino)propylpiperidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 351528-79-5
4-cyano-4-(2-cyanophenyl)piperidine

: 268205-04-5
4-(2-Cyanophenyl)-4-cyano-N-(3-[N-{1,1-dimethyl ethoxycarbonyl}]amino)propylpiperidine

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/jm990612y

Reference yield:

: 3759-28-2
(2-cyanophenyl)acetonitrile

: 268205-04-5
4-(2-Cyanophenyl)-4-cyano-N-(3-[N-{1,1-dimethyl ethoxycarbonyl}]amino)propylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: Cs₂CO₃ / dimethylsulfoxide / 24 h / 20 °C

2: HCl(g) / ethyl acetate / 0.08 h / 0 °C

3: Et₃N / dimethylformamide / 15 h / 20 °C

With hydrogenchloride; caesium carbonate; triethylamine; In dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; 1: Cycloaddition / 2: Acidolysis / 3: Alkylation;
DOI:10.1021/jm990612y