(E)-3-[2-n-butyl-1-{(2,3-dichlorophenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

Base Information

Chemical Name:(E)-3-[2-n-butyl-1-{(2,3-dichlorophenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid
CAS No.:133485-84-4
Molecular Formula:C₂₂H₂₂Cl₂N₂O₂S
Molecular Weight:449.401
Hs Code.:

Synonyms:(E)-3-[2-n-butyl-1-{(2,3-dichlorophenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

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Chemical Property of (E)-3-[2-n-butyl-1-{(2,3-dichlorophenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

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Technology Process of (E)-3-[2-n-butyl-1-{(2,3-dichlorophenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

There total 8 articles about (E)-3-[2-n-butyl-1-{(2,3-dichlorophenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-3-[2-Butyl-3-(2,3-dichloro-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid ethyl ester

: 133485-84-4
(E)-3-[2-n-butyl-1-{(2,3-dichlorophenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 17h; Ambient temperature;
DOI:10.1021/jm00065a011

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 133485-84-4
(E)-3-[2-n-butyl-1-{(2,3-dichlorophenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine; benzoic acid / cyclohexane / 20 h / Heating

2: sodium tetrahydroborate / ethanol / 0 °C

3: potassium hydroxide / ethanol / 48 h / Ambient temperature

4: piperidine; benzoic acid / toluene / 18 h / Heating

5: sodium hydroxide / ethanol / 17 h / Ambient temperature

With piperidine; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; benzoic acid; In ethanol; cyclohexane; toluene;
DOI:10.1021/jm00065a011

Reference yield:

: 30313-06-5
diethyl 2-(thiophen-2-ylmethylene)malonate

: 133485-84-4
(E)-3-[2-n-butyl-1-{(2,3-dichlorophenyl)methyl}-1H-imidazol-5-yl]-2-(thien-2-yl)methyl-2-propenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol / 0 °C

2: potassium hydroxide / ethanol / 48 h / Ambient temperature

3: piperidine; benzoic acid / toluene / 18 h / Heating

4: sodium hydroxide / ethanol / 17 h / Ambient temperature

With piperidine; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; benzoic acid; In ethanol; toluene;
DOI:10.1021/jm00065a011