C₁₀H₁₀BrNO₂

Base Information

• Chemical Name: C₁₀H₁₀BrNO₂
• CAS No.: 1313227-69-8
• Molecular Formula: C₁₀H₁₀BrNO₂
• Molecular Weight: 256.099
• Mol file: 1313227-69-8.mol

Synonyms:C₁₀H₁₀BrNO₂

Chemical Property of C₁₀H₁₀BrNO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₁₀BrNO₂

There total 2 articles about C₁₀H₁₀BrNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-methylene-5-phenyl-2-(trimethylsilyloxy)isoxazolidine (1198015-31-4) → C10H10BrNO2 (1313227-69-8)

Guidance literature:

With bromine; acetic acid; triethylamine; In dichloromethane; at -78 ℃; for 0.25h; Inert atmosphere;

DOI:10.1016/j.tet.2011.04.078

Reference yield:

3-methyl-5-phenyl-4,5-dihydroisoxazole 2-oxide (127525-90-0) → C10H10BrNO2 (1313227-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / -78 °C / Inert atmosphere

2: bromine; acetic acid; triethylamine / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

With bromine; acetic acid; triethylamine; In dichloromethane;

DOI:10.1016/j.tet.2011.04.078

Reference yield: 84.0%

C10H10BrNO2 (1313227-69-8) + malonic acid dimethyl ester (108-59-8) → C15H17NO6 (1313227-85-8)

Guidance literature:

malonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere;

C₁₀H₁₀BrNO₂; In tetrahydrofuran; mineral oil; at -40 - 0 ℃; for 0.75h; Inert atmosphere;

DOI:10.1016/j.tet.2011.04.078

upstream raw materials:

3-methylene-5-phenyl-2-(trimethylsilyloxy)isoxazolidine

3-methyl-5-phenyl-4,5-dihydroisoxazole 2-oxide

Downstream raw materials:

C₁₅H₁₇NO₆