2-Chloro-5-hydroxypyrimidine

Base Information

• Chemical Name: 2-Chloro-5-hydroxypyrimidine
• CAS No.: 4983-28-2
• Molecular Formula: C4H3ClN2O
• Molecular Weight: 130.534
• Hs Code.: 29335990
• Mol file: 4983-28-2.mol

Synonyms:2-Chloropyrimidin-5-ol;

Chemical Property of 2-Chloro-5-hydroxypyrimidine

Chemical Property:

• Melting Point: 195-196 °C
• Boiling Point: 328.1 °C at 760 mmHg
• PKA: 6.17±0.23(Predicted)
• Flash Point: 152.3 °C
• PSA: 46.01000
• Density: 1.513 g/cm³
• LogP: 0.83560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-hydroxypyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-5-hydroxypyrimidine is an intermediate used to synthesize tandospirone derivatives with anxiolytic activities.

Technology Process of 2-Chloro-5-hydroxypyrimidine

There total 5 articles about 2-Chloro-5-hydroxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloro-5-methoxy-pyrimidine (22536-65-8) → 2-chloropyrimidine-5-ol (4983-28-2)

Guidance literature:

With hydrogen bromide; DL-methionine; In acetic acid; for 5h; Reflux;

Reference yield: 67.0%

2-Chloro-5-(dimethylaminomethyleneamino)pyrimidine (56622-03-8) → 2-chloropyrimidine-5-ol (4983-28-2)

Guidance literature:

With sulfuric acid; Heating;

DOI:10.1007/BF00756420

Reference yield: 33.0%

2-chloro-5-aminopyrimidine (56621-90-0) → 2-chloropyrimidine-5-ol (4983-28-2)

Guidance literature:

With sulfuric acid; water; Reflux;

DOI:10.1021/jm901381j

upstream raw materials:

2-Chloro-5-(dimethylaminomethyleneamino)pyrimidine

2-chloro-5-methoxy-pyrimidine

2-chloro-5-aminopyrimidine

(2-chloropyrimidin-5-yl)boronic acid

Downstream raw materials:

5-(benzyloxy)-2-chloropyrimidine

2-chloro-5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidine

2-chloro-5-(1-(2,6-dichloro-3,5-dimethoxyphenyl)ethoxy)pyrimidine

2-chloro-5-[(2,6-dichloro-3,5-dimethoxybenzyl)oxy]pyrimidine

Refernces

• 1、 -. "FGFR4 INHIBITORS". Page/Page column 50. . Retrieved 2016/10/31.
• 2、 -. "NEUROPROTECTIVE MULTIFUNCTIONAL ANTIOXIDANTS AND THEIR MONOFUNCTIONAL ANALOGS". Paragraph 0094. . Retrieved 2014/09/03.