(S)-2-[(4-fluorobenzenesulfonyl)(methyl)amino]-3-methoxy-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)propionamide

Base Information

Chemical Name:(S)-2-[(4-fluorobenzenesulfonyl)(methyl)amino]-3-methoxy-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)propionamide
CAS No.:1590397-34-4
Molecular Formula:C₂₅H₂₄F₄N₂O₄S
Molecular Weight:524.536
Hs Code.:

Synonyms:(S)-2-[(4-fluorobenzenesulfonyl)(methyl)amino]-3-methoxy-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[(4-fluorobenzenesulfonyl)(methyl)amino]-3-methoxy-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)propionamide

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Technology Process of (S)-2-[(4-fluorobenzenesulfonyl)(methyl)amino]-3-methoxy-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)propionamide

There total 7 articles about (S)-2-[(4-fluorobenzenesulfonyl)(methyl)amino]-3-methoxy-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: (S)-2-(4-fluorobenzenesulfonylamino)-3-methoxypropionic acid 4'-trifluoromethylbiphenyl-3-ylmethyl ester

: 74-88-4
methyl iodide

: 1590397-34-4
(S)-2-[(4-fluorobenzenesulfonyl)(methyl)amino]-3-methoxy-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)propionamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 14h;

Reference yield:

: C₁₈H₁₉F₃N₂O₂

: 1590397-34-4
(S)-2-[(4-fluorobenzenesulfonyl)(methyl)amino]-3-methoxy-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water

1.2: 3 h / 25 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 14 h

With water; potassium carbonate; sodium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: (S)-2-tert-butoxycarbonylamino-3-methoxypropionic acid 4'-trifluoromethylbiphenyl-3-ylmethyl ester

: 1590397-34-4
(S)-2-[(4-fluorobenzenesulfonyl)(methyl)amino]-3-methoxy-N-(4'-trifluoromethylbiphenyl-3-ylmethyl)propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h

2.1: sodium hydroxide; water

2.2: 3 h / 25 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 14 h

With water; potassium carbonate; trifluoroacetic acid; sodium hydroxide; In dichloromethane; N,N-dimethyl-formamide;