N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

Base Information

Chemical Name:N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate
CAS No.:1410809-52-7
Molecular Formula:C₂HF₃O₂*C₂₁H₂₅N₃O₄
Molecular Weight:497.471
Hs Code.:

N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

Synonyms:N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

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Chemical Property of N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

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Technology Process of N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

There total 10 articles about N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1410810-09-1
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

: 76-05-1
trifluoroacetic acid

: 1410809-52-7
N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

Guidance literature:: (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate; With hydrogenchloride; In 1,4-dioxane; methanol; for 1h;

With hydroxylamine; In Isopropyl acetate; at 4 ℃; for 40h;

trifluoroacetic acid;

Reference yield:

: 81997-76-4
(S,E)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropionic acid ethyl ester

: 1410809-52-7
N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

1.2: 1 h

2.1: triethylamine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: diethylzinc / hexane / 16 h / -20 - 20 °C / Inert atmosphere

3.2: Cooling

4.1: acetic acid / 15 h / 20 °C

5.1: sodium periodate; sodium hydrogencarbonate / water / 2 h / 20 °C

6.1: potassium carbonate; methanol / 5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h / 20 °C

8.2: 0 °C / pH 3

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

10.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h

10.2: 40 h / 4 °C

With hydrogenchloride; methanol; sodium periodate; lithium hydroxide monohydrate; water; diethylzinc; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide;

Reference yield:

: 135502-12-4
(+)-(2E,4S)-4,5-isopropylidenedioxy-2-methylpent-2-enyl acetate

: 1410809-52-7
N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethylzinc / hexane / 16 h / -20 - 20 °C / Inert atmosphere

1.2: Cooling

2.1: acetic acid / 15 h / 20 °C

3.1: sodium periodate; sodium hydrogencarbonate / water / 2 h / 20 °C

4.1: potassium carbonate; methanol / 5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h / 20 °C

6.2: 0 °C / pH 3

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

8.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h

8.2: 40 h / 4 °C

With hydrogenchloride; methanol; sodium periodate; lithium hydroxide monohydrate; water; diethylzinc; sodium hydrogencarbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide;