(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Base Information

Chemical Name:(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate
CAS No.:1410810-09-1
Molecular Formula:C₂₇H₃₄N₂O₆
Molecular Weight:482.577
Hs Code.:

Synonyms:(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

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Chemical Property of (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Chemical Property:

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Technology Process of (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

There total 9 articles about (S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093192-07-4
(S)-2-amino-3-(tert-butoxycarbonylamino)-3-methylbutanoic acid methyl ester

: 1410810-08-0
4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzoic acid

: 1410810-09-1
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 81997-76-4
(S,E)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropionic acid ethyl ester

: 1410810-09-1
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

1.2: 1 h

2.1: triethylamine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: diethylzinc / hexane / 16 h / -20 - 20 °C / Inert atmosphere

3.2: Cooling

4.1: acetic acid / 15 h / 20 °C

5.1: sodium periodate; sodium hydrogencarbonate / water / 2 h / 20 °C

6.1: potassium carbonate; methanol / 5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

8.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h / 20 °C

8.2: 0 °C / pH 3

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With methanol; sodium periodate; lithium hydroxide monohydrate; water; diethylzinc; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;

Reference yield:

: 135502-12-4
(+)-(2E,4S)-4,5-isopropylidenedioxy-2-methylpent-2-enyl acetate

: 1410810-09-1
(S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-(((1S,2R)-2-(hydroxymethyl)-2-methylcyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethylzinc / hexane / 16 h / -20 - 20 °C / Inert atmosphere

1.2: Cooling

2.1: acetic acid / 15 h / 20 °C

3.1: sodium periodate; sodium hydrogencarbonate / water / 2 h / 20 °C

4.1: potassium carbonate; methanol / 5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 15 h / 20 °C

6.2: 0 °C / pH 3

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

With methanol; sodium periodate; lithium hydroxide monohydrate; water; diethylzinc; sodium hydrogencarbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;