4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol

Base Information

Chemical Name:4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol
CAS No.:1260668-12-9
Molecular Formula:C₂₂H₁₇ClFNOS
Molecular Weight:397.9
Hs Code.:

Synonyms:4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol

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Chemical Property of 4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol

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Technology Process of 4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol

There total 3 articles about 4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 165612-80-6
C₁₆H₁₂ClFO₂

: 137-07-5
2-amino-benzenethiol

: 1260668-12-9
4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol

Guidance literature:: With ammonium cerium (IV) nitrate; In ethanol; at 60 - 65 ℃; for 0.466667h; Ultrasonic irradiation;
DOI:10.5012/jkcs.2011.55.5.776

Reference yield: 69.0%

: 1260667-96-6
(E)-1-(5-chloro-2-hydroxy-4-methylphenyl)-3-(4-fluorophenyl)prop-2-en-1-one

: 137-07-5
2-amino-benzenethiol

: 1260668-12-9
4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol

Guidance literature:: (E)-1-(5-chloro-2-hydroxy-4-methylphenyl)-3-(4-fluorophenyl)prop-2-en-1-one; 2-amino-benzenethiol; In ethanol; for 3h; Reflux;

With acetic acid; In ethanol; for 3h; Reflux;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 459-57-4
4-fluorobenzaldehyde

: 1260668-12-9
4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / 20 °C

2: ammonium cerium (IV) nitrate / ethanol / 0.47 h / 60 - 65 °C / Ultrasonic irradiation

With ammonium cerium (IV) nitrate; potassium hydroxide; In ethanol; 1: Claisen- Schmidt condensation;
DOI:10.5012/jkcs.2011.55.5.776