(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

Base Information

Chemical Name:(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate
CAS No.:1206486-33-0
Molecular Formula:C₅₃H₇₇N₅O₈Si
Molecular Weight:940.309
Hs Code.:

(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

Synonyms:(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

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Chemical Property of (S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

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Technology Process of (S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

There total 2 articles about (S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 75-30-9
2-iodo-propane

: 1189587-52-7
(S)-benzyl 2-((S)-2-((E)-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-2-nitroacrylamido)-4-methylpentanamido)-3-methylbutanoate

: 1189587-53-8
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

: 1206486-33-0
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

Guidance literature:: 2-iodo-propane; (S)-benzyl 2-((S)-2-((E)-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-2-nitroacrylamido)-4-methylpentanamido)-3-methylbutanoate; With triethyl borane; oxygen; tri-n-butyl-tin hydride; zinc trifluoromethanesulfonate; In dichloromethane; at -78 - 20 ℃; for 3h; Inert atmosphere;

With hydrogenchloride; water; In dichloromethane;

With methanol; samarium diiodide; In tetrahydrofuran; at 20 ℃; for 0.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.200902425

Reference yield: 16.0%

: 75-30-9
2-iodo-propane

: 1189587-52-7
(S)-benzyl 2-((S)-2-((E)-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-2-nitroacrylamido)-4-methylpentanamido)-3-methylbutanoate

: 1206486-33-0
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

: 1206486-35-2
C₅₃H₇₇N₅O₈Si

: 1189587-53-8
(S)-benzyl 2-((S)-2-(2-amino-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-4-methylpentanamido)-4-methylpentanamido)-3-methylbutanoate

Guidance literature:: (S)-benzyl 2-((S)-2-((E)-3-(3-((S)-2-(benzyloxycarbonylamino)-3-tert-butoxy-3-oxopropyl)-2-(triethylsilyl)-1H-indol-6-yl)-2-nitroacrylamido)-4-methylpentanamido)-3-methylbutanoate; With zinc trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 0.0166667h;

2-iodo-propane; With triethyl borane; oxygen; tri-n-butyl-tin hydride; In dichloromethane; at -78 ℃; for 2.5h; Inert atmosphere;

With samarium diiodide; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ja909870g