10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

Base Information

Chemical Name:10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel
CAS No.:653586-90-4
Molecular Formula:C₆₀H₉₁NO₁₈Si₂
Molecular Weight:1170.55
Hs Code.:

Synonyms:10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

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Chemical Property of 10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

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Technology Process of 10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

There total 9 articles about 10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: (3R,4S)-1-(tert-butoxycarbonyl)-4-(furan-2-yl)-3-(triisopropylsilyloxy)azetidin-2-one

: 564476-29-5
7-(triethylsilyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-baccatin III

: 653586-90-4
10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 - -20 ℃; for 1h;

Reference yield:

: 173422-40-7
(3R,4R)-1-(tert-butoxycarbonyl)-4-(furan-2-yl)-3-(triisopropylsilyloxy)azetidin-2-one

: 564476-29-5
7-(triethylsilyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-baccatin III

: 653586-90-4
10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmcl.2004.09.025

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 653586-90-4
10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / dimethylformamide / 20 °C

2: Red-Al / tetrahydrofuran / 20 °C

3: 90 percent / DCC; 4-PP / toluene / 60 °C

4: HF; pyridine / tetrahydrofuran / 0 - 20 °C

5: CeCl₃ / tetrahydrofuran / 20 °C

6: imidazole / dimethylformamide / 20 °C

7: NaH / tetrahydrofuran / 20 °C

With pyridine; 1H-imidazole; cerium(III) chloride; hydrogen fluoride; sodium hydride; dicyclohexyl-carbodiimide; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2004.09.025