564476-29-5

Upstream product

• 994-30-9 triethylsilyl chloride 
• 108-24-7 acetic anhydride 
• 564476-27-3 2-debenzoyl-2-(2,5-dimethoxybenzoyl)-10-deacetylbaccatin 
• 2785-98-0 2,5-dimethoxybenzoic acid 
• 564476-26-2 C₄₉H₈₂O₁₂Si₃ 
• 204580-30-3 10-O-deacetyl-2-O-debenzoyl-7,10,13-O-tris(triethylsilyl)baccatin III 
• 194720-19-9 7,10,13-tris(triethylsilyl)-10-deacetylbaccatin III 
• 32981-86-5 10-deacetylbaccatin III 
• 810683-27-3 C₃₃H₄₂O₁₃ 

Downstream Products

• 564476-30-8 C₆₀H₉₅NO₁₇Si₂ 
• 653586-90-4 10-acetoxy-7-(triethylsilyl)-2'-(triisopropylsilyloxy)-3'-dephenyl-3'-(2-furyl)-2-debenzoyl-2-(2,5-dimethoxybenzoyl)-docetaxel 
• 653586-74-4 C₅₉H₉₁NO₁₆Si₂ 
• 653586-75-5 C₆₀H₉₃NO₁₆Si₂ 
• 653586-88-0 C₆₀H₈₉NO₁₇Si₂ 
• 653587-07-6 C₅₉H₈₇NO₁₆SSi₂ 
• 653586-87-9 C₅₉H₈₇NO₁₇Si₂ 
• 653586-89-1 C₆₂H₈₇NO₁₇Si₂ 
• 653586-91-5 C₆₀H₈₅NO₁₈Si₂ 
• 653587-08-7 C₆₀H₈₉NO₁₆SSi₂ 
• 653587-10-1 C₆₀H₉₁NO₁₇SSi₂ 
• 653587-11-2 C₆₀H₈₅NO₁₇SSi₂ 
• 653587-09-8 C₆₂H₈₇NO₁₆SSi₂ 

Relevant academic research and scientific papers

Facile method for synthesizing baccatin III compounds

A process for synthesizing a C-7 protected baccatin III compound represented by formula (A), which comprises reacting a 10-deacetylbaccatin III compound represented by formula (B) with a protecting agent and an acylating agent in the presence of a secondary amine and a nitrogen-containing compound. Also, a process for synthesizing a C-7 protected 10-deacetylbaccatin III compound represented by formula (C), which comprises reacting a 10-deacetylbaccatin III compound represented by formula (B) with a protecting agent in the presence of a secondary amine and a nitrogen-containing compound. In both processes the nitrogen-containing compound is selected from a nitrogen-containing heterocycle or a trialkylamine. When the nitrogen-containing heterocycle is selected, it may be an unsubstituted or a substituted pyridine or an unsubstituted or a substituted pyrazine. When a trialkylamine is selected, it may be, for example, triethylamine or diisopropylethylamine. wherein PG1 represents the organic residue of the protecting agent, PG2 represents the organic residue of the acylating agent, and R represents a simple or substituted aryl group or a heterocyclic group.

Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors

The use of drug-antibody conjugates affords a method for the targeted delivery of anticancer drugs specifically to cancer cells. Monoclonal antibodies alone usually do not possess high therapeutic efficacy, however, they are capable of targeting tumor mar

Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies

The targeted delivery of taxoids, in the form of taxane-antibody immunoconjugates, requires the preparation of taxoids containing moieties suitable for their conjugation to monoclonal antibodies. A series of taxoids incorporating a disulfide-containing li

Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use

A cytotoxic agent comprising one or more polyethylene glycol-containing taxanes linked to a cell binding agent. A therapeutic composition for killing selected cell populations comprising: (A) a cytotoxic amount of one or more polyethylene glycol-containing taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient. A method for killing selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more polyethylene glycol-containing taxanes linked to a cell binding agent.