N-benzyl-N-(3-oxopentyl)-(E)-3-(4-methoxyphenyl)propenamide

Base Information

• Chemical Name: N-benzyl-N-(3-oxopentyl)-(E)-3-(4-methoxyphenyl)propenamide
• CAS No.: 1039361-97-1
• Molecular Formula: C₂₂H₂₅NO₃
• Molecular Weight: 351.445
• Mol file: 1039361-97-1.mol

Synonyms:N-benzyl-N-(3-oxopentyl)-(E)-3-(4-methoxyphenyl)propenamide

Chemical Property of N-benzyl-N-(3-oxopentyl)-(E)-3-(4-methoxyphenyl)propenamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-benzyl-N-(3-oxopentyl)-(E)-3-(4-methoxyphenyl)propenamide

There total 1 articles about N-benzyl-N-(3-oxopentyl)-(E)-3-(4-methoxyphenyl)propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H17NO (742028-84-8) + p-methoxycinnamoyl chloride (42996-84-9,34446-64-5) → N-benzyl-N-(3-oxopentyl)-(E)-3-(4-methoxyphenyl)propenamide (1039361-97-1)

Guidance literature:

With sodium carbonate; In dichloromethane; water; at 20 ℃; for 20h;

DOI:10.1021/ol800883b

Reference yield: 70.0%

N-benzyl-N-(3-oxopentyl)-(E)-3-(4-methoxyphenyl)propenamide (1039361-97-1) + triethylaluminum (97-93-8) → (3RS,4RS)-1-benzyl-4-ethyl-4-hydroxy-3-[(RS)-1-(4-methoxyphenyl)propyl]piperidin-2-one

Guidance literature:

N-benzyl-N-(3-oxopentyl)-(E)-3-(4-methoxyphenyl)propenamide; With bis-acetylacetonatocobalt(II) dihydrate; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

triethylaluminum; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 17h; diastereoselective reaction;

DOI:10.1021/ol800883b

upstream raw materials:

C₁₂H₁₇NO

p-methoxycinnamoyl chloride