3-(4-Methoxyphenyl)acryloyl chloride

Base Information

• Chemical Name: 3-(4-Methoxyphenyl)acryloyl chloride
• CAS No.: 42996-84-9
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.633
• Hs Code.: 2918990090
• European Community (EC) Number: 626-984-7
• Nikkaji Number: J1.057.123E,J1.057.305J
• Wikidata: Q76416360
• Mol file: 42996-84-9.mol

Synonyms:42996-84-9;3-(4-Methoxyphenyl)acryloyl chloride;34446-64-5;4-METHOXYCINNAMOYL CHLORIDE;TRANS-4-METHOXYCINNAMOYL CHLORIDE;(2E)-3-(4-methoxyphenyl)acryloyl chloride;4-methoxycinnamoylchloride;(E)-3-(4-methoxyphenyl)prop-2-enoyl Chloride;(2E)-3-(4-methoxyphenyl)prop-2-enoyl chloride;(E)-3-(4-Methoxyphenyl)acryloyl chloride;trans-3-(4-Methoxyphenyl)-acryloyl chloride;trans-3-(4-Methoxyphenyl)-acryloyl chloride;4-methoxycinnamic acid chloride;p-Methoxycinnamic acid chloride;SCHEMBL145711;(E)-4-methoxycinnamoyl chloride;CGOJOQBYEAVATL-QPJJXVBHSA-N;BBL015036;MFCD00039314;STL197445;3-(4-Methoxyphenyl)propenoyl chloride;AKOS005173513;A851295;2-Propenoyl chloride, 3-(4-methoxyphenyl)-, (E)-

Chemical Property of 3-(4-Methoxyphenyl)acryloyl chloride

Chemical Property:

• PSA: 26.30000
• LogP: 2.47380
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 196.0291072
• Heavy Atom Count: 13
• Complexity: 193

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2E)-3-(4-methoxyphenyl)acryloylchloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 22-34-42/43
• Safety Statements: 22-24-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=CC(=O)Cl
• Isomeric SMILES: COC1=CC=C(C=C1)/C=C/C(=O)Cl

Technology Process of 3-(4-Methoxyphenyl)acryloyl chloride

There total 21 articles about 3-(4-Methoxyphenyl)acryloyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-3-(4-methoxyphenyl)acrylic acid (943-89-5) → (E)-3-(4-methoxyphenyl)propenoyl chloride (34446-64-5,42996-84-9)

Guidance literature:

With oxalyl dichloride;

DOI:10.1016/S0040-4020(00)00088-0

Reference yield: 98.0%

3-(4'-methoxyphenyl)propenoic acid (830-09-1) → p-methoxycinnamoyl chloride (42996-84-9,34446-64-5)

Guidance literature:

With thionyl chloride; In 1,2-dichloro-ethane; for 3h; Heating;

Reference yield: 95.0%

oxalyl dichloride (79-37-8) + (E)-3-(4-methoxyphenyl)acrylic acid (943-89-5) → (E)-3-(4-methoxyphenyl)propenoyl chloride (34446-64-5,42996-84-9)

Guidance literature:

In toluene; for 20h; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19981216)81:12<2270::AID-HLCA2270>3.0.CO;2-#

upstream raw materials:

3-(4'-methoxyphenyl)propenoic acid

4-hydroxy-benzaldehyde

4-methoxy-benzaldehyde

para-coumaric acid

Downstream raw materials:

3-(4-methoxyphenyl)-N-(4-methoxyphenyl)prop-(2E)-enamide

1-benzooxazol-2-yl-4-[3-(4-methoxy-phenyl)-acryloyl]-piperazine

1-(5-chloro-benzooxazol-2-yl)-4-[3-(4-methoxy-phenyl)-acryloyl]-piperazine

1-(5-chloro-benzothiazol-2-yl)-4-[3-(4-methoxy-phenyl)-acryloyl]-piperazine