Technology Process of 1,3,2',6'-tetra-N-benzyl-3'-O-(8''-bromooctyl)-1,3,2'-tri-N-tert-butoxycarbonyl-6'-N,4'-O-carbonyl-5,6-O-cyclohexylideneneamine
There total 8 articles about 1,3,2',6'-tetra-N-benzyl-3'-O-(8''-bromooctyl)-1,3,2'-tri-N-tert-butoxycarbonyl-6'-N,4'-O-carbonyl-5,6-O-cyclohexylideneneamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
dimethyl sulfoxide;
at 20 ℃;
for 0.5h;
DOI:10.1021/jo000589k
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 69 percent
2.1: 74 percent / imidazole / dimethylformamide / 20 °C
3.1: NaH / dimethylformamide / 2 h / 20 °C
3.2: 79 percent / dimethylformamide / 6 h / 20 °C
4.1: 66 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.17 h
5.1: 98 percent / KOH / dimethylsulfoxide / 0.5 h / 20 °C
With
1H-imidazole; potassium hydroxide; tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo000589k
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 83 percent / Et3N
2.1: 69 percent
3.1: 74 percent / imidazole / dimethylformamide / 20 °C
4.1: NaH / dimethylformamide / 2 h / 20 °C
4.2: 79 percent / dimethylformamide / 6 h / 20 °C
5.1: 66 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.17 h
6.1: 98 percent / KOH / dimethylsulfoxide / 0.5 h / 20 °C
With
1H-imidazole; potassium hydroxide; tetrabutyl ammonium fluoride; sodium hydride; triethylamine;
In
tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo000589k
