methylenebisphosphonic acid benzyl trimethyl ester

Base Information

• Chemical Name: methylenebisphosphonic acid benzyl trimethyl ester
• CAS No.: 503306-09-0
• Molecular Formula: C₁₁H₁₈O₆P₂
• Molecular Weight: 308.208
• Mol file: 503306-09-0.mol

Synonyms:methylenebisphosphonic acid benzyl trimethyl ester

Chemical Property of methylenebisphosphonic acid benzyl trimethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of methylenebisphosphonic acid benzyl trimethyl ester

There total 1 articles about methylenebisphosphonic acid benzyl trimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Benzyl methyl chlorophosphate (133660-55-6) + dimethyl methane phosphonate (756-79-6) → methylenebisphosphonic acid benzyl trimethyl ester (503306-09-0)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

Benzyl methyl chlorophosphate; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Further stages.;

DOI:10.1002/1521-3765(20021018)8:20<4649::AID-CHEM4649>3.0.CO;2-M

Reference yield: 78.0%

methylenebisphosphonic acid benzyl trimethyl ester (503306-09-0) → difluoromethylenebisphosphonic acid benzyl trimethyl ester (503306-30-7)

Guidance literature:

methylenebisphosphonic acid benzyl trimethyl ester; With sodium hydride; In tetrahydrofuran; at -10 - 20 ℃; for 0.166667h;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; at -10 - 0 ℃; Further stages.;

DOI:10.1002/1521-3765(20021018)8:20<4649::AID-CHEM4649>3.0.CO;2-M

upstream raw materials:

Benzyl methyl chlorophosphate

dimethyl methane phosphonate

Downstream raw materials:

difluoromethylenebisphosphonic acid benzyl trimethyl ester