Benzyl methyl chlorophosphate

Base Information

• Chemical Name: Benzyl methyl chlorophosphate
• CAS No.: 133660-55-6
• Molecular Formula: C₈H₁₀ClO₃P
• Molecular Weight: 220.592
• Mol file: 133660-55-6.mol

Synonyms:Benzyl methyl chlorophosphate

Chemical Property of Benzyl methyl chlorophosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl methyl chlorophosphate

There total 1 articles about Benzyl methyl chlorophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dibenzyl methyl phosphate (26292-51-3) → Benzyl methyl chlorophosphate (133660-55-6)

Guidance literature:

With Quinuclidine; oxalyl dichloride; Yield given. Multistep reaction; 1.) toluene, reflux; 2.) toluene, DMF;

DOI:10.1016/0040-4039(95)00865-A

Reference yield: 93.0%

1,2-benzenedimethanamine (17300-02-6) + Benzyl methyl chlorophosphate (133660-55-6) → <2-<<<(Benzyloxy)methoxyphosphoryl>amino>methyl>benzyl>phosphoramidic acid benzyl ester methyl ester

Guidance literature:

With triethylamine; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jo00117a019

Reference yield: 60.0%

Benzyl methyl chlorophosphate (133660-55-6) + dimethyl methane phosphonate (756-79-6) → methylenebisphosphonic acid benzyl trimethyl ester (503306-09-0)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

Benzyl methyl chlorophosphate; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Further stages.;

DOI:10.1002/1521-3765(20021018)8:20<4649::AID-CHEM4649>3.0.CO;2-M

upstream raw materials:

dibenzyl methyl phosphate

Downstream raw materials:

methylenebisphosphonic acid benzyl trimethyl ester

difluoromethylenebisphosphonic acid benzyl trimethyl ester