N-methoxy-1-tosylmethanimidoyl cyanide

Base Information

• Chemical Name: N-methoxy-1-tosylmethanimidoyl cyanide
• CAS No.: 74754-99-7
• Molecular Formula: C₁₀H₁₀N₂O₃S
• Molecular Weight: 238.267
• Mol file: 74754-99-7.mol

Synonyms:N-methoxy-1-tosylmethanimidoyl cyanide

Chemical Property of N-methoxy-1-tosylmethanimidoyl cyanide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methoxy-1-tosylmethanimidoyl cyanide

There total 3 articles about N-methoxy-1-tosylmethanimidoyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C9H8N2O3S (175201-58-8) + dimethyl sulfate (77-78-1) → N-methoxy-1-tosylmethanimidoyl cyanide (74754-99-7)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2013.09.051

Reference yield:

p-tolylsulfonylmethyl isocyanide (5697-44-9) → N-methoxy-1-tosylmethanimidoyl cyanide (74754-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: isopentyl nitrite; sodium ethanolate / ethanol / 24 h / 20 °C

2: potassium carbonate / tetrahydrofuran / 3 h / 20 °C

With sodium ethanolate; potassium carbonate; isopentyl nitrite; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2013.09.051

Reference yield:

methyl iodide (74-88-4) → N-methoxy-1-tosylmethanimidoyl cyanide (74754-99-7)

Guidance literature:

With ethanol;

upstream raw materials:

methyl iodide

C₉H₈N₂O₃S

dimethyl sulfate

p-tolylsulfonylmethyl isocyanide

Refernces