tert-butyl N-[1-[4-(4-chloro-2,7-naphthyridin-3-yl)phenyl]-cyclobutyl]carbamate

Base Information

Chemical Name:tert-butyl N-[1-[4-(4-chloro-2,7-naphthyridin-3-yl)phenyl]-cyclobutyl]carbamate
CAS No.:1357158-99-6
Molecular Formula:C₂₃H₂₄ClN₃O₂
Molecular Weight:409.915
Hs Code.:

Synonyms:tert-butyl N-[1-[4-(4-chloro-2,7-naphthyridin-3-yl)phenyl]-cyclobutyl]carbamate

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Chemical Property of tert-butyl N-[1-[4-(4-chloro-2,7-naphthyridin-3-yl)phenyl]-cyclobutyl]carbamate

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Technology Process of tert-butyl N-[1-[4-(4-chloro-2,7-naphthyridin-3-yl)phenyl]-cyclobutyl]carbamate

There total 6 articles about tert-butyl N-[1-[4-(4-chloro-2,7-naphthyridin-3-yl)phenyl]-cyclobutyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1357158-98-5
tert-butyl N-[1-[4-[2-[3-[methoxyiminomethyl]pyridin-4-yl]ethynyl]phenyl]cyclobutyl]carbamate

: 1357158-99-6
tert-butyl N-[1-[4-(4-chloro-2,7-naphthyridin-3-yl)phenyl]-cyclobutyl]carbamate

Guidance literature:: With copper dichloride; In N,N-dimethyl acetamide; at 100 ℃; Inert atmosphere;
DOI:10.1021/jm201394e

Reference yield:

: 1301610-33-2
tert-butyl 1-(4-ethynylphenyl)cyclobutylcarbamate

: 1357158-99-6
tert-butyl N-[1-[4-(4-chloro-2,7-naphthyridin-3-yl)phenyl]-cyclobutyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / 20 °C / Inert atmosphere

2: triethylamine / 20 °C / Inert atmosphere

3: copper dichloride / N,N-dimethyl acetamide / 100 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; copper dichloride; In N,N-dimethyl acetamide; acetonitrile; 1: Suzuki coupling;
DOI:10.1021/jm201394e

Reference yield:

: 1032350-06-3
tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

: 1357158-99-6
tert-butyl N-[1-[4-(4-chloro-2,7-naphthyridin-3-yl)phenyl]-cyclobutyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine / tetrahydrofuran / 70 °C / Inert atmosphere

2: potassium carbonate / methanol / 20 °C / Inert atmosphere

3: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / 20 °C / Inert atmosphere

4: triethylamine / 20 °C / Inert atmosphere

5: copper dichloride / N,N-dimethyl acetamide / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; triphenylphosphine; copper dichloride; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; acetonitrile; 3: Suzuki coupling;
DOI:10.1021/jm201394e