2-{4-[2-(4-bromophenyl)-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl]phenylamino}benzonitrile

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Chemical Name:2-{4-[2-(4-bromophenyl)-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl]phenylamino}benzonitrile
CAS No.:1293912-73-8
Molecular Formula:C₃₅H₂₅BrN₂O₃S
Molecular Weight:633.565
Hs Code.:

Synonyms:2-{4-[2-(4-bromophenyl)-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl]phenylamino}benzonitrile

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Chemical Property of 2-{4-[2-(4-bromophenyl)-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl]phenylamino}benzonitrile

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Technology Process of 2-{4-[2-(4-bromophenyl)-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl]phenylamino}benzonitrile

There total 4 articles about 2-{4-[2-(4-bromophenyl)-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl]phenylamino}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1293912-72-7
5-(4-bromophenyl)-4-(4-bromophenylsulfonyl)-2,2-diphenyl-2,3-dihydrofuran

: 1885-29-6
anthranilic acid nitrile

: 1293912-73-8
2-{4-[2-(4-bromophenyl)-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl]phenylamino}benzonitrile

: 1293912-74-9
2-(4-{2-[4-(2-cyanophenylamino)phenyl]-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl}phenylamino)benzonitrile

Guidance literature:: With 18-crown-6 ether; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 70 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.02.049

Reference yield:

: 86516-54-3
1-(4-bromophenyl)-2-(4-bromophenylsulfonyl)ethanone

: 1293912-73-8
2-{4-[2-(4-bromophenyl)-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl]phenylamino}benzonitrile

: 1293912-74-9
2-(4-{2-[4-(2-cyanophenylamino)phenyl]-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl}phenylamino)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: copper diacetate; manganese triacetate / acetic acid / 1 h / 80 °C / Microwave irradiation

2: 18-crown-6 ether; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 12 h / 70 °C / Inert atmosphere

With 18-crown-6 ether; copper diacetate; palladium diacetate; manganese triacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In acetic acid; toluene; 2: Buchwald-Hartwig reaction;
DOI:10.1016/j.tetlet.2011.02.049

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1293912-73-8
2-{4-[2-(4-bromophenyl)-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl]phenylamino}benzonitrile

: 1293912-74-9
2-(4-{2-[4-(2-cyanophenylamino)phenyl]-5,5-diphenyl-4,5-dihydrofuran-3-ylsulfonyl}phenylamino)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; sodium sulfite / water / 0.33 h / 100 °C / Microwave irradiation

1.2: 0.75 h / 100 °C / Microwave irradiation

2.1: copper diacetate; manganese triacetate / acetic acid / 1 h / 80 °C / Microwave irradiation

3.1: 18-crown-6 ether; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 12 h / 70 °C / Inert atmosphere

With 18-crown-6 ether; copper diacetate; palladium diacetate; manganese triacetate; sodium hydrogencarbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium sulfite; In water; acetic acid; toluene; 3.1: Buchwald-Hartwig reaction;
DOI:10.1016/j.tetlet.2011.02.049