(R)-N-4'-((3''-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide

Base Information

Chemical Name:(R)-N-4'-((3''-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide
CAS No.:1197982-79-8
Molecular Formula:C₂₀H₂₃FN₂O₄
Molecular Weight:374.412
Hs Code.:

Synonyms:(R)-N-4'-((3''-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-4'-((3''-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide

Chemical Property:

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Technology Process of (R)-N-4'-((3''-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide

There total 8 articles about (R)-N-4'-((3''-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1226776-24-4
C₁₈H₂₁FN₂O₃*ClH

: 75-36-5
acetyl chloride

: 1197982-79-8
(R)-N-4'-((3''-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1197983-10-0
(R)-N-(4-(3-fluorobenzyloxy)benzyl)-2-amino-3-methoxypropionamide

: 75-36-5
acetyl chloride

: 1197982-79-8
(R)-N-4'-((3''-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm100185c

Reference yield:

: 831216-51-4
4-((3'-fluoro)benzyloxy)benzonitrile

: 1197982-79-8
(R)-N-4'-((3''-fluoro)benzyloxy)benzyl 2-acetamido-3-methoxypropionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

1.2: 0 - 20 °C

2.1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3.1: silver(l) oxide / acetonitrile / 72 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 0 - 20 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; triethylamine; silver(l) oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;