Technology Process of N-{1-[2-(2,2-dimethoxyethyl)phenyl]-2-nitroethyl}-N-phenylacetamide
There total 3 articles about N-{1-[2-(2,2-dimethoxyethyl)phenyl]-2-nitroethyl}-N-phenylacetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Acetanilid;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
(E)-2-[2-(2-nitrovinyl)phenyl]acetaldehyde dimethyl acetal;
In
tetrahydrofuran;
at 0 - 5 ℃;
for 8h;
DOI:10.1016/j.bmc.2003.12.036
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 79 percent / methanesulfonyl chloride; Et3N / CH2Cl2 / 8 h / 0 °C
2.1: NaH / tetrahydrofuran / 0.17 h / 0 °C
2.2: 60 percent / tetrahydrofuran / 8 h / 0 - 5 °C
With
sodium hydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2003.12.036
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 79 percent / KOH / methanol; H2O / 7 h / 0 °C
2.1: 79 percent / methanesulfonyl chloride; Et3N / CH2Cl2 / 8 h / 0 °C
3.1: NaH / tetrahydrofuran / 0.17 h / 0 °C
3.2: 60 percent / tetrahydrofuran / 8 h / 0 - 5 °C
With
potassium hydroxide; sodium hydride; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water;
1.1: Henry reaction;
DOI:10.1016/j.bmc.2003.12.036