(2E)-3-(4-Cyanophenyl)-N-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

Base Information

Chemical Name:(2E)-3-(4-Cyanophenyl)-N-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide
CAS No.:1299479-92-7
Molecular Formula:C₂₀H₁₄F₆N₂O
Molecular Weight:412.334
Hs Code.:

Synonyms:(2E)-3-(4-Cyanophenyl)-N-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E)-3-(4-Cyanophenyl)-N-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

Chemical Property:

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Technology Process of (2E)-3-(4-Cyanophenyl)-N-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

There total 3 articles about (2E)-3-(4-Cyanophenyl)-N-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1299479-75-6
(2E)-3-(4-Cyanophenyl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}acrylamide

: 74-88-4
methyl iodide

: 1299479-92-7
(2E)-3-(4-Cyanophenyl)-N-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 18h;

Reference yield:

: 16642-94-7,18664-39-6
(E)-4-cyanocinnamic acid

: 1299479-92-7
(2E)-3-(4-Cyanophenyl)-N-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride

2: triethylamine / dichloromethane / 18 h / 20 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 18 h / 0 - 20 °C

With oxalyl dichloride; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 97190-62-0
(E)-4-cyanocinnamoyl chloride

: 65686-68-2,1213368-14-9,1213841-80-5
2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethanamine

: 1299479-92-7
(2E)-3-(4-Cyanophenyl)-N-methyl-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]-ethyl}acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 18 h / 0 - 20 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;