N-[2-((2R,4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethyl]-2,2,2-trifluoro-acetamide

Base Information

Chemical Name:N-[2-((2R,4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethyl]-2,2,2-trifluoro-acetamide
CAS No.:917082-49-6
Molecular Formula:C₂₆H₂₉F₃N₂O₇
Molecular Weight:538.521
Hs Code.:

Synonyms:N-[2-((2R,4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethyl]-2,2,2-trifluoro-acetamide

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Chemical Property of N-[2-((2R,4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethyl]-2,2,2-trifluoro-acetamide

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Technology Process of N-[2-((2R,4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethyl]-2,2,2-trifluoro-acetamide

There total 4 articles about N-[2-((2R,4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethyl]-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 917082-48-5
2-(trifluoroacetylamino)ethyl 2-acetylamino-4,6-O-benzylidene-2-deoxy-β-D-glucopyranoside

: 100-39-0
benzyl bromide

: 917082-49-6
N-[2-((2R,4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethyl]-2,2,2-trifluoro-acetamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; kerosene; at -20 ℃;
DOI:10.1007/s11178-006-0043-7

Reference yield:

: N-[2-((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-ethyl]-2,2,2-trifluoro-acetamide

: 917082-49-6
N-[2-((2R,4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 742 mg / camphorsulfonic acid / acetonitrile / 2 h / 75 °C

2: 85 percent / sodium hydride / dimethylformamide; kerosene / -20 °C

With camphor-10-sulfonic acid; sodium hydride; In N,N-dimethyl-formamide; acetonitrile; kerosene;
DOI:10.1007/s11178-006-0043-7

Reference yield:

: 917082-47-4
2-(trifluoroacetylamino)ethyl 2-acetylamino-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranoside

: 917082-49-6
N-[2-((2R,4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-ethyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methoxide; KU-2 (H+) cation exchanger / methanol / 1 h / 20 °C

2: 742 mg / camphorsulfonic acid / acetonitrile / 2 h / 75 °C

3: 85 percent / sodium hydride / dimethylformamide; kerosene / -20 °C

With KU-2 (H+) cation exchanger; camphor-10-sulfonic acid; sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide; acetonitrile; kerosene;
DOI:10.1007/s11178-006-0043-7