ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate

Base Information

Chemical Name:ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate
CAS No.:1369917-49-6
Molecular Formula:C₂₃H₃₇NO₆S
Molecular Weight:455.616
Hs Code.:

Synonyms:ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate

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Chemical Property of ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate

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Technology Process of ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate

There total 5 articles about ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369917-48-5
C₂₉H₅₁NO₆SSi

: 1369917-49-6
ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1248/cpb.59.1494

Reference yield:

: C₂₀H₃₄O₅SSi

: 1369917-49-6
ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.42 h / 0 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1248/cpb.59.1494

Reference yield:

: 1369917-42-9
methyl (2E,4S)-4-(tert-butyldimethylsilyloxy)-5-[3-(methoxymethyl)phenyl]-2-pentenoate

: 1369917-49-6
ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -70 - -20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 0.42 h / 0 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1248/cpb.59.1494