7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid

Base Information

Chemical Name:7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid
CAS No.:1369917-02-1
Molecular Formula:C₂₁H₃₃NO₆S
Molecular Weight:427.562
Hs Code.:

Synonyms:7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid

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Chemical Property of 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid

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Technology Process of 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid

There total 6 articles about 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1369917-49-6
ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate

: 1369917-02-1
7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid

Guidance literature:: ethyl 7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]-2-penten-1-yl}(methylsulfonyl)amino]heptanoate; With water; sodium hydroxide; In methanol; at 20 ℃; for 1.5h;

With hydrogenchloride; In methanol; water; Cooling with ice;
DOI:10.1248/cpb.59.1494

Reference yield:

: C₂₀H₃₄O₅SSi

: 1369917-02-1
7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.42 h / 0 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.1: water; sodium hydroxide / methanol / 1.5 h / 20 °C

3.2: Cooling with ice

With tetrabutyl ammonium fluoride; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1248/cpb.59.1494

Reference yield:

: 1369917-42-9
methyl (2E,4S)-4-(tert-butyldimethylsilyloxy)-5-[3-(methoxymethyl)phenyl]-2-pentenoate

: 1369917-02-1
7-[{(2E,4S)-4-hydroxy-5-[3-(methoxymethyl)phenyl]pent-2-enyl}-(methylsulfonyl)amino]heptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -70 - -20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 0.42 h / 0 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

5.1: water; sodium hydroxide / methanol / 1.5 h / 20 °C

5.2: Cooling with ice

With tetrabutyl ammonium fluoride; water; sodium hydride; diisobutylaluminium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1248/cpb.59.1494