tert-butyl (2R,3S,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate

Base Information

Chemical Name:tert-butyl (2R,3S,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate
CAS No.:1003280-32-7
Molecular Formula:C₃₁H₄₉NO₃Si
Molecular Weight:511.82
Hs Code.:

Synonyms:tert-butyl (2R,3S,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate

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Chemical Property of tert-butyl (2R,3S,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate

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Technology Process of tert-butyl (2R,3S,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate

There total 1 articles about tert-butyl (2R,3S,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 161554-77-4
tert-butyl (S,E)-4-(tert-butyldimethylsilyloxy)pent-2-enoate

: 74-88-4
methyl iodide

: tert-butyl (2S,3R,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate

: 1003280-32-7
tert-butyl (2R,3S,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

tert-butyl (S,E)-4-(tert-butyldimethylsilyloxy)pent-2-enoate; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h; Further stages.;
DOI:10.1039/b712937h

Reference yield: 88.0%

: 1003280-32-7
tert-butyl (2R,3S,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate

: 1003280-49-6
(3S,4S,5S,αR)-3,5-dimethyl-4-[N-benzyl-N-(α-methylbenzyl)amino]tetrahydro-2-furanone

Guidance literature:: tert-butyl (2R,3S,4S,αR)-2-methyl-3-[N-benzyl-N-(α-methylbenzyl)amino]-4-(tert-butyldimethylsilyloxy)pentanoate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 50 ℃; for 24h;

With trifluoroacetic acid; In toluene; at 20 ℃; for 24h; Further stages.;
DOI:10.1039/b712937h