Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester
CAS No.:500767-39-5
Molecular Formula:C₃₁H₃₆F₃N₅O₇S
Molecular Weight:679.717
Hs Code.:

Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester

Synonyms:Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester

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Chemical Property of Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester

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Technology Process of Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester

There total 13 articles about Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Trifluoro-methanesulfonic acid 3-{(S)-2-[benzyloxycarbonyl-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butyl)-amino]-2-carbamoyl-ethyl}-phenyl ester

: 500767-39-5
Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester

Guidance literature:: With ammonium formate; In ethanol; at 20 ℃;
DOI:10.1021/jm020951i

Reference yield:

: 587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2
m-tyrosine

: 500767-39-5
Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: AcCl / 20 °C

2: NH₃ / methanol / 20 °C

3: 77 percent / aq. NaHCO₃ / tetrahydrofuran / 20 °C

4: 89 percent / K₂CO₃; Et₃N / CH₂Cl₂ / 0.5 h / Heating

5: TFA / CH₂Cl₂ / 0.25 h

6: 79 percent / propan-2-ol / Heating

7: 78 percent / aq. Na₂CO₃ / tetrahydrofuran / 0.5 h / 20 °C

8: HCl / ethyl acetate / 20 °C

9: 0.17 g / TBTU; DIEA / dimethylformamide / 20 °C

10: HCl / ethyl acetate / 20 °C

11: TBTU; DIEA / dimethylformamide; CH₂Cl₂ / 20 °C

12: 60 mg / ammonium formate; 10percent Pd/C / ethanol / 20 °C

With hydrogenchloride; ammonia; ammonium formate; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm020951i

Reference yield:

: 167935-97-9
methyl (S)-2-amino-3-(3-hydroxyphenyl)propanoate

: 500767-39-5
Trifluoro-methanesulfonic acid 3-[(S)-2-carbamoyl-2-((2S,3S)-2-hydroxy-3-{(S)-3-methyl-2-[(pyridine-2-carbonyl)-amino]-butyrylamino}-4-phenyl-butylamino)-ethyl]-phenyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: NH₃ / methanol / 20 °C

2: 77 percent / aq. NaHCO₃ / tetrahydrofuran / 20 °C

3: 89 percent / K₂CO₃; Et₃N / CH₂Cl₂ / 0.5 h / Heating

4: TFA / CH₂Cl₂ / 0.25 h

5: 79 percent / propan-2-ol / Heating

6: 78 percent / aq. Na₂CO₃ / tetrahydrofuran / 0.5 h / 20 °C

7: HCl / ethyl acetate / 20 °C

8: 0.17 g / TBTU; DIEA / dimethylformamide / 20 °C

9: HCl / ethyl acetate / 20 °C

10: TBTU; DIEA / dimethylformamide; CH₂Cl₂ / 20 °C

11: 60 mg / ammonium formate; 10percent Pd/C / ethanol / 20 °C

With hydrogenchloride; ammonia; ammonium formate; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm020951i