L-Phenylalanine, 3-hydroxy-, methyl ester

Base Information

• Chemical Name: L-Phenylalanine, 3-hydroxy-, methyl ester
• CAS No.: 167935-97-9
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Mol file: 167935-97-9.mol

Synonyms:(S)-2-Amino-3-(3-hydroxy-phenyl)-propionic acid methyl ester;L-Phenylalanine, 3-hydroxy-, methyl ester;Methyl-L-m-tyrosinat;L-m-Tyr-OMe;methyl L-m-tyrosinate;

Chemical Property of L-Phenylalanine, 3-hydroxy-, methyl ester

Chemical Property:

• PSA: 72.55000
• LogP: 1.13530

Purity/Quality:

Min98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Phenylalanine, 3-hydroxy-, methyl ester

There total 19 articles about L-Phenylalanine, 3-hydroxy-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-methyl 2-((benzyloxycarbonyl)amino)-3-(3-hydroxyphenyl)propanoate (234122-64-6) → methyl (S)-2-amino-3-(3-hydroxyphenyl)propanoate (167935-97-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 12h;

Reference yield: 86.0%

2-azido-3-(3-benzyloxy-phenyl)-propionic acid methyl ester → methyl (S)-2-amino-3-(3-hydroxyphenyl)propanoate (167935-97-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1016/S0960-894X(02)00227-5

Reference yield: 31.8%

methanol (67-56-1) + m-tyrosine (587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2) → methyl (S)-2-amino-3-(3-hydroxyphenyl)propanoate (167935-97-9)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.1016/j.bmcl.2018.03.020

upstream raw materials:

methanol

m-tyrosine

(S)-methyl 2-((benzyloxycarbonyl)amino)-3-(3-hydroxyphenyl)propanoate

Fmoc-3-hydroxy-L-Phe

Downstream raw materials:

2S-tert-butoxycarbonylamino-3-(3-hydroxyphenyl)propionic acid methyl ester

(S)-N^α-tert-butoxycarbonyl-(m-benzyloxy)phenylalanine methyl ester

(S)-3-(3-(benzyloxy)phenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-methylbutanamido)propanoic acid

(S)-1-[(S)-3-(3-Benzyloxy-phenyl)-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propionyl]-hexahydro-pyridazine-3-carboxylic acid methyl ester