(3R)-3-(4-bromophenyl)sulfanyltetrahydrofuran

Base Information

• Chemical Name: (3R)-3-(4-bromophenyl)sulfanyltetrahydrofuran
• CAS No.: 1286238-66-1
• Molecular Formula: C₁₀H₁₁BrOS
• Molecular Weight: 259.167
• Mol file: 1286238-66-1.mol

Synonyms:(3R)-3-(4-bromophenyl)sulfanyltetrahydrofuran

Chemical Property of (3R)-3-(4-bromophenyl)sulfanyltetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-3-(4-bromophenyl)sulfanyltetrahydrofuran

There total 1 articles about (3R)-3-(4-bromophenyl)sulfanyltetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S)-3-iodotetrahydrofuran (918439-76-6) + para-bromobenzenethiol (106-53-6) → (3R)-3-(4-bromophenyl)sulfanyltetrahydrofuran (1286238-66-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm101488z

Reference yield: 57.0%

(3R)-3-(4-bromophenyl)sulfanyltetrahydrofuran (1286238-66-1) → (3R)-3-(4-bromophenyl)sulfonyltetrahydrofuran (1286238-65-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

Reference yield:

(3R)-3-(4-bromophenyl)sulfanyltetrahydrofuran (1286238-66-1) → (R)-3-amino-N-phenyl-6-(4-((tetrahydrofuran-3-yl)sulfonyl)-phenyl)pyrazine-2-carboxamide (1286238-57-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; water; 3: Suzuki coupling;

DOI:10.1021/jm101488z

upstream raw materials:

(3S)-3-iodotetrahydrofuran

para-bromobenzenethiol

Downstream raw materials:

(R)-3-amino-N-phenyl-6-(4-((tetrahydrofuran-3-yl)sulfonyl)-phenyl)pyrazine-2-carboxamide

(3R)-3-(4-bromophenyl)sulfonyltetrahydrofuran