2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1H-indole

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Chemical Name:2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1H-indole
CAS No.:109463-79-8
Molecular Formula:C₂₂H₃₅NOSi
Molecular Weight:357.611
Hs Code.:

Synonyms:2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1H-indole

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Chemical Property of 2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1H-indole

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Technology Process of 2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1H-indole

There total 5 articles about 2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 100414-86-6
[(1R,2R)-2-(1H-Indol-2-yl)-2-methyl-cyclohexyl]-methanol

: 109463-79-8
2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1H-indole

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 0.25h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90586-1

Reference yield:

: 95-53-4
o-toluidine

: 109463-79-8
2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / LiI, cyclohexene oxide / chlorotrimethylsilane / neat (no solvent) / 20 h / Heating

2: 1.) n-BuLi / 1.) hexane, 0 deg C, 5 min., reflux, 6.5 h; 2.) THF, -78 deg C, 15 min.,warmed to room temp.

3: 82 percent / imidazole / dimethylformamide / 0.25 h / Ambient temperature

With 1H-imidazole; n-butyllithium; cyclohexane-1,2-epoxide; lithium iodide; chloro-trimethyl-silane; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)90586-1

Reference yield:

: 82185-43-1
N-(trimethylsilyl)-o-toluidine

: 109463-79-8
2-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-1-methyl-cyclohexyl]-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) hexane, 0 deg C, 5 min., reflux, 6.5 h; 2.) THF, -78 deg C, 15 min.,warmed to room temp.

2: 82 percent / imidazole / dimethylformamide / 0.25 h / Ambient temperature

With 1H-imidazole; n-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)90586-1