5-{[(9H-fluoren-9-yl-methoxycarbonylamino)-phenyl-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl}-pentanoic acid 2-oxo-2-phenyl-ethyl ester

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Chemical Name:5-{[(9H-fluoren-9-yl-methoxycarbonylamino)-phenyl-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl}-pentanoic acid 2-oxo-2-phenyl-ethyl ester
CAS No.:918950-33-1
Molecular Formula:C₄₃H₄₀NO₈P
Molecular Weight:729.766
Hs Code.:

Synonyms:5-{[(9H-fluoren-9-yl-methoxycarbonylamino)-phenyl-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl}-pentanoic acid 2-oxo-2-phenyl-ethyl ester

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Chemical Property of 5-{[(9H-fluoren-9-yl-methoxycarbonylamino)-phenyl-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl}-pentanoic acid 2-oxo-2-phenyl-ethyl ester

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Technology Process of 5-{[(9H-fluoren-9-yl-methoxycarbonylamino)-phenyl-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl}-pentanoic acid 2-oxo-2-phenyl-ethyl ester

There total 3 articles about 5-{[(9H-fluoren-9-yl-methoxycarbonylamino)-phenyl-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl}-pentanoic acid 2-oxo-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 918950-51-3
5-{[(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl-methyl]-hydroxy-phosphinoyl}-pentanoic acid

: 70-11-1
α-bromoacetophenone

: 918950-33-1
5-{[(9H-fluoren-9-yl-methoxycarbonylamino)-phenyl-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl}-pentanoic acid 2-oxo-2-phenyl-ethyl ester

Guidance literature:: With triethylamine; In ethyl acetate; at 20 ℃;
DOI:10.1021/jo061535z

Reference yield:

: 918950-48-8
5-hydroxyphosphinoyl-pentanoic acid

: 918950-33-1
5-{[(9H-fluoren-9-yl-methoxycarbonylamino)-phenyl-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl}-pentanoic acid 2-oxo-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / acetyl chloride; acetic acid / 4 h / 20 °C

2: 91 percent / triethylamine / ethyl acetate / 20 °C

With acetic acid; triethylamine; acetyl chloride; In ethyl acetate;
DOI:10.1021/jo061535z

Reference yield:

: 591-80-0
pent-4-enoic acid

: 918950-33-1
5-{[(9H-fluoren-9-yl-methoxycarbonylamino)-phenyl-methyl]-(2-oxo-2-phenyl-ethoxy)-phosphinoyl}-pentanoic acid 2-oxo-2-phenyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NH₄H₂PO₂; triethylborane / methanol; hexane / 2 h / 20 °C

2: 87 percent / acetyl chloride; acetic acid / 4 h / 20 °C

3: 91 percent / triethylamine / ethyl acetate / 20 °C

With ammonium hypophosphorous acid; triethyl borane; acetic acid; triethylamine; acetyl chloride; In methanol; hexane; ethyl acetate;
DOI:10.1021/jo061535z