(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

Base Information

Chemical Name:(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole
CAS No.:260417-78-5
Molecular Formula:C₂₇H₃₀N₂O₈
Molecular Weight:510.544
Hs Code.:

Synonyms:(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

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Chemical Property of (2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

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Technology Process of (2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

There total 3 articles about (2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 260417-80-9
(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methoxybenzoyl]-2-(tert-butyldimethylsilyloxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

: 260417-78-5
(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

Guidance literature:: With acetic acid; In tetrahydrofuran; water;
DOI:10.1016/S0960-894X(00)00351-6

Reference yield: 40.0%

: (2S)-N-(2-amino-4-benzyloxy-5-methyloxybenzoyl)-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

: 2937-50-0
Allyl chloroformate

: 260417-78-5
(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 2.5h;

Reference yield:

: 260417-69-4
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

: 260417-78-5
(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NaH / tetrahydrofuran / 0 °C

2: 90 percent / AcOH / tetrahydrofuran; H₂O

With sodium hydride; acetic acid; In tetrahydrofuran; water; 1: Condensation / 2: desilylation;
DOI:10.1016/S0960-894X(00)00351-6