(11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Base Information

Chemical Name:(11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
CAS No.:260417-79-6
Molecular Formula:C₂₇H₂₈N₂O₈
Molecular Weight:508.528
Hs Code.:

(11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Synonyms:(11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

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Chemical Property of (11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

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Technology Process of (11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

There total 3 articles about (11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 260417-78-5
(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methyloxybenzoyl]-2-(hydroxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

: 260417-79-6
(11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -45 ℃;
DOI:10.1016/S0960-894X(00)00351-6

Reference yield:

: 260417-69-4
{5-benzyloxy-2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-4-oxo-pyrrolidine-1-carbonyl]-4-methoxy-phenyl}-carbamic acid allyl ester

: 260417-79-6
(11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / NaH / tetrahydrofuran / 0 °C

2: 90 percent / AcOH / tetrahydrofuran; H₂O

3: 66 percent / (COCl)2; DMSO / CH₂Cl₂ / -45 °C

With oxalyl dichloride; sodium hydride; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water; 1: Condensation / 2: desilylation / 3: Cyclization;
DOI:10.1016/S0960-894X(00)00351-6

Reference yield:

: 260417-80-9
(2S)-N-[(2-allyloxycarbonylamino)-4-benzyloxy-5-methoxybenzoyl]-2-(tert-butyldimethylsilyloxymethyl)-4-(methoxycarbonylmethyl)-2,3-dihydropyrrole

: 260417-79-6
(11S,11aS)-10-allyloxycarbonyl-8-benzyloxy-11-hydroxy-7-methoxy-2-(methoxycarbonylmethyl)-1,10,11,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / AcOH / tetrahydrofuran; H₂O

2: 66 percent / (COCl)2; DMSO / CH₂Cl₂ / -45 °C

With oxalyl dichloride; acetic acid; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; water; 1: desilylation / 2: Cyclization;
DOI:10.1016/S0960-894X(00)00351-6