benzyl 4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1H-pyrrolo[2,3-b]pyridine-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

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Chemical Name:benzyl 4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1H-pyrrolo[2,3-b]pyridine-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate
CAS No.:1338811-44-1
Molecular Formula:C₃₉H₃₅N₅O₅
Molecular Weight:653.737
Hs Code.:

Synonyms:benzyl 4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1H-pyrrolo[2,3-b]pyridine-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

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Chemical Property of benzyl 4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1H-pyrrolo[2,3-b]pyridine-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

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Technology Process of benzyl 4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1H-pyrrolo[2,3-b]pyridine-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

There total 7 articles about benzyl 4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1H-pyrrolo[2,3-b]pyridine-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338811-43-0
Benzyl-4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

: 1338811-44-1
benzyl 4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1H-pyrrolo[2,3-b]pyridine-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; at 50 ℃; for 5h;

Reference yield:

: 74420-15-8
3-bromo-1H-pyrrolo[2,3-b]pyridine

: 1338811-44-1
benzyl 4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1H-pyrrolo[2,3-b]pyridine-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 85 °C / Inert atmosphere

4.1: sodium hydroxide / 1,4-dioxane / 5 h / 50 °C

With potassium acetate; sodium hydride; caesium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;

Reference yield:

: 271-63-6
7-Azaindole

: 1338811-44-1
benzyl 4-((2-(2,4-dimethoxybenzyl)-1-oxo-7-(1H-pyrrolo[2,3-b]pyridine-3-yl)-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl)benzylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 4 h / -40 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

4.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 85 °C / Inert atmosphere

5.1: sodium hydroxide / 1,4-dioxane / 5 h / 50 °C

With N-Bromosuccinimide; potassium acetate; sodium hydride; caesium carbonate; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;