1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-hydroxy-2-methylene-3-phenylpropanoate

Base Information

Chemical Name:1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-hydroxy-2-methylene-3-phenylpropanoate
CAS No.:253197-70-5
Molecular Formula:C₁₃H₁₀F₆O₃
Molecular Weight:328.211
Hs Code.:

Synonyms:1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-hydroxy-2-methylene-3-phenylpropanoate

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Chemical Property of 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-hydroxy-2-methylene-3-phenylpropanoate

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Technology Process of 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-hydroxy-2-methylene-3-phenylpropanoate

There total 1 articles about 1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-hydroxy-2-methylene-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2160-89-6
1,1,1,3,3,3-hexafluoroisopropyl acrylate

: 100-52-7
benzaldehyde

: 253197-70-5
1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-hydroxy-2-methylene-3-phenylpropanoate

: 1,1,1,3,3,3-hexafluoropropan-2-yl (S)-3-hydroxy-2-methylene-3-phenylpropanoate

Guidance literature:: With (3R,8R,9S)-10,11-dihydro-3,9-epoxy-6'-hydroxy-cinchonane; In N,N-dimethyl-formamide; at -55 ℃; for 48h; Title compound not separated from byproducts;
DOI:10.1021/ja992655+

Reference yield: 100.0%

: 253197-70-5
1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-hydroxy-2-methylene-3-phenylpropanoate

: 18020-59-2,98837-37-7,108945-27-3,140630-33-7
methyl (R)-3-hydroxy-3-phenyl-2-methylenepropanoate

Guidance literature:: With sodium hydrogencarbonate; In methanol; at 20 ℃; for 24h;
DOI:10.1002/ejoc.201700337

Reference yield:

: 253197-70-5
1,1,1,3,3,3-hexafluoropropan-2-yl (R)-3-hydroxy-2-methylene-3-phenylpropanoate

: 1,1,1,3,3,3-hexafluoropropan-2-yl (3R,4S,5R)-3-hydroxy-5-triethylsiloxy-4-methyl-2-methylene-5-phenylpentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / methanol / 24 h / 20 °C

2: hydrogen; (bicyclo[2.2.1]hepta-2,5-diene)[1,4-bis(diphenylphosphanyl)butane]rhodium(I) trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 0.5 h / 0 °C

4: diisobutylaluminium hydride / dichloromethane; hexane / 1 h / -94 °C

5: α-isocupreine / tetrahydrofuran; N,N-dimethyl-formamide / 72 h / -55 °C

With dmap; (bicyclo[2.2.1]hepta-2,5-diene)[1,4-bis(diphenylphosphanyl)butane]rhodium(I) trifluoromethanesulfonate; α-isocupreine; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 5: |Morita-Baylis-Hillman Alkylation;
DOI:10.1002/ejoc.201700337