4-(3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol

Base Information

• Chemical Name: 4-(3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol
• CAS No.: 484644-46-4
• Molecular Formula: C₂₀H₂₃N₃O₂
• Molecular Weight: 337.422
• Mol file: 484644-46-4.mol

Synonyms:4-(3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol

Chemical Property of 4-(3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol

There total 2 articles about 4-(3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-aminopyridine (504-29-0) + Cyclohexyl isocyanide (931-53-3) + vanillin (121-33-5,8014-42-4) → 4-(3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol (484644-46-4)

Guidance literature:

With β-cyclodextrin-SO₃H; In ethanol; at 80 ℃; for 1h;

DOI:10.1021/acs.joc.9b00208

Reference yield:

→ 4-(3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol (484644-46-4)

Guidance literature:

Reference yield: 83.0%

4-(3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenol (484644-46-4) → 2-aminopyridine (504-29-0) + N-cyclohexyl-2-(4-hydroxy-3-methoxyphenyl)-2-oxoacetamide

Guidance literature:

With [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid; In 1,2-dichloro-ethane; at 20 ℃; for 1h; chemoselective reaction; Schlenk technique;

DOI:10.1021/acs.joc.9b00208

upstream raw materials:

2-aminopyridine

Cyclohexyl isocyanide

vanillin

Downstream raw materials:

2-aminopyridine