N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide

Base Information

Chemical Name:N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide
CAS No.:1355460-64-8
Molecular Formula:C₅₄H₇₆N₆O₉
Molecular Weight:953.232
Hs Code.:

Synonyms:N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide

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Chemical Property of N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide

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Technology Process of N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide

There total 5 articles about N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1355460-63-7
4-(benzamido)butyl p-toluene sulfonate

: 1355460-62-6
1,1'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis(2-methoxy-4,1-phenylene)]dipiperazine

: 1355460-64-8
N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; at 80 ℃; for 16h;
DOI:10.1016/j.bmc.2011.10.063

Reference yield:

: 37860-51-8
tetraethylene glycol di(p-toluenesulfonate)

: 1355460-64-8
N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.25 h / 0 °C

1.2: 0 - 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 18 h / 115 °C

3.1: potassium carbonate; sodium iodide / acetonitrile / 16 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; sodium iodide; johnphos; sodium t-butanolate; In tetrahydrofuran; toluene; acetonitrile; paraffin oil;
DOI:10.1016/j.bmc.2011.10.063

Reference yield:

: 1355460-61-5
1,15-bis(4-bromo-3-methoxyphenyl)-2,5,8,11,14-pentaoxapentadecane

: 1355460-64-8
N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; johnphos; sodium t-butanolate / toluene / 18 h / 115 °C

2: potassium carbonate; sodium iodide / acetonitrile / 16 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; sodium iodide; johnphos; sodium t-butanolate; In toluene; acetonitrile;
DOI:10.1016/j.bmc.2011.10.063