Technology Process of N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide
There total 5 articles about N,N'-[2,5,8,11,14-pentaoxapentadecane-1,15-diylbis[(2-methoxy-4,1-phenylene)piperazine-4,1-diylbutane-4,1-diyl]]dibenzamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate; sodium iodide;
In
acetonitrile;
at 80 ℃;
for 16h;
DOI:10.1016/j.bmc.2011.10.063
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.25 h / 0 °C
1.2: 0 - 20 °C
2.1: tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate / toluene / 18 h / 115 °C
3.1: potassium carbonate; sodium iodide / acetonitrile / 16 h / 80 °C
With
tris-(dibenzylideneacetone)dipalladium(0); sodium hydride; potassium carbonate; sodium iodide; johnphos; sodium t-butanolate;
In
tetrahydrofuran; toluene; acetonitrile; paraffin oil;
DOI:10.1016/j.bmc.2011.10.063
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate / toluene / 18 h / 115 °C
2: potassium carbonate; sodium iodide / acetonitrile / 16 h / 80 °C
With
tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; sodium iodide; johnphos; sodium t-butanolate;
In
toluene; acetonitrile;
DOI:10.1016/j.bmc.2011.10.063