9H-fluoren-9-ylmethyl N-[3-[[4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzoyl]amino]ethyl]carbamate

Base Information

Chemical Name:9H-fluoren-9-ylmethyl N-[3-[[4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzoyl]amino]ethyl]carbamate
CAS No.:1609659-38-2
Molecular Formula:C₃₉H₃₃N₅O₄
Molecular Weight:635.722
Hs Code.:

Synonyms:9H-fluoren-9-ylmethyl N-[3-[[4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzoyl]amino]ethyl]carbamate

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Chemical Property of 9H-fluoren-9-ylmethyl N-[3-[[4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzoyl]amino]ethyl]carbamate

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Technology Process of 9H-fluoren-9-ylmethyl N-[3-[[4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzoyl]amino]ethyl]carbamate

There total 3 articles about 9H-fluoren-9-ylmethyl N-[3-[[4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzoyl]amino]ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1609659-34-8
4-[3-[4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethylcarbamoyl]phenyl]indazol-1-yl]benzoic acid

: 593-51-1
methylamine hydrochloride

: 1609659-38-2
9H-fluoren-9-ylmethyl N-[3-[[4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzoyl]amino]ethyl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;
DOI:10.1002/anie.201310240

Reference yield:

: 279249-34-2
4-[3-(4-methoxycarbonylphenyl)indazol-1-yl]benzoic acid

: 1609659-38-2
9H-fluoren-9-ylmethyl N-[3-[[4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzoyl]amino]ethyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 6 h / 60 °C

2: potassium carbonate / 1,4-dioxane; water / 0 - 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201310240

Reference yield:

: 1609659-33-7
4-[3-[4-(2-aminoethylcarbamoyl)phenyl]indazol-1-yl]benzoic acid

: 1609659-38-2
9H-fluoren-9-ylmethyl N-[3-[[4-[1-[4-(methylcarbamoyl)phenyl]indazol-3-yl]benzoyl]amino]ethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / 1,4-dioxane; water / 0 - 20 °C

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201310240