C₃₂H₃₃NO₅

Base Information

• Chemical Name: C₃₂H₃₃NO₅
• CAS No.: 1155288-15-5
• Molecular Formula: C₃₂H₃₃NO₅
• Molecular Weight: 511.618
• Mol file: 1155288-15-5.mol

Synonyms:C₃₂H₃₃NO₅

Chemical Property of C₃₂H₃₃NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₃NO₅

There total 16 articles about C₃₂H₃₃NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1002727-88-9) + C23H24INO4 (1155288-13-3) → C32H33NO5 (1155288-15-5)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 110 ℃; for 0.25h; Microwave irradiation;

Reference yield:

2,3-dihydro-4H-1-benzopyran-4-one (491-37-2) → C32H33NO5 (1155288-15-5)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; zinc / 100 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 5 h / 95 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.25 h / 110 °C / Microwave irradiation

With potassium acetate; potassium carbonate; acetic acid; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; 3: Suzuki Coupling;

Reference yield:

diethyl acetylsuccinate (1115-30-6) → C32H33NO5 (1155288-15-5)

Guidance literature:

Multi-step reaction with 13 steps

1.1: Amberlyst_.(R). 15 / toluene / 72 h / Heating / reflux

2.1: diphenylether / 0.1 h / 100 - 250 °C

3.1: trichlorophosphate / 2.5 h / Heating / reflux

4.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 0.67 h / 20 °C

4.2: 16 h / Heating / reflux

4.3: 20 °C

5.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C

5.2: 0.5 h / -78 °C

5.3: -78 - 20 °C

6.1: perchloric acid / 2 h / 20 °C

6.2: pH ~ 6

7.1: sodium hydroxide; water / ethanol / 4 h / 20 °C

7.2: pH ~ 3 - ~ 4

8.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5.5 h / 30 - 35 °C

8.2: 16 h / 20 °C

9.1: lithium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C

9.2: pH ~ 4 - ~ 5

10.1: diethyl ether

11.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 24 h / 75 °C

12.1: potassium carbonate / N,N-dimethyl-formamide / 1 h

13.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.25 h / 110 °C / Microwave irradiation

With hydrogenchloride; lithium hydroxide; sodium hydroxide; N-Bromosuccinimide; perchloric acid; water; dihydrogen peroxide; potassium hexamethylsilazane; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; diphenylether; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; 13.1: Suzuki Coupling;

upstream raw materials:

2-(chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

C₂₃H₂₄INO₄

chromane

2,3-dihydro-4H-1-benzopyran-4-one

Downstream raw materials:

C₃₁H₃₁NO₅

Refernces