2,6-Difluorobenzhydrazide

Base Information

• Chemical Name: 2,6-Difluorobenzhydrazide
• CAS No.: 172935-91-0
• Molecular Formula: C7H6 F2 N2 O
• Molecular Weight: 172.134
• Hs Code.: 2928000090
• European Community (EC) Number: 673-661-1
• DSSTox Substance ID: DTXSID80350292
• Wikidata: Q72462606
• Mol file: 172935-91-0.mol

Synonyms:2,6-Difluorobenzhydrazide;172935-91-0;2,6-difluorobenzohydrazide;2,6-difluorobenzoyl hydrazine;2,6-difluorobenzoic acid hydrazide;Benzoic acid, 2,6-difluoro-, hydrazide;2,6-difluoro benzoyl hydrazine;2,6-difluorobenzoylhydrazine;2,6-difluorobenzoic hydrazide;2,6-difluorobenzylhydrazine;SCHEMBL1127907;DTXSID80350292;GVZACAPOZBPAMJ-UHFFFAOYSA-N;MFCD00119406;AKOS000160965;SB86286;CS-0207150;EN300-250315

Chemical Property of 2,6-Difluorobenzhydrazide

Chemical Property:

• PSA: 55.12000
• LogP: 1.65950
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 172.04481914
• Heavy Atom Count: 12
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

2,6-Difluorobenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)F)C(=O)NN)F

Technology Process of 2,6-Difluorobenzhydrazide

There total 4 articles about 2,6-Difluorobenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2,6-difluorobenzoate (13671-00-6) → 2,6-difluorobenzoic hydrazide (172935-91-0)

Guidance literature:

With hydrazine hydrate; In methanol; for 5h; Reflux;

DOI:10.1007/s00044-016-1514-1

Reference yield:

→ 2,6-difluorobenzoic hydrazide (172935-91-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 25 - 30 ℃;

Reference yield:

2,6-Difluorobenzoic acid,ethyl ester (19064-14-3) → 2,6-difluorobenzoic hydrazide (172935-91-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 17h; Heating;

DOI:10.1016/j.tet.2007.11.099

upstream raw materials:

2,6-Difluorobenzoic acid,ethyl ester

methyl 2,6-difluorobenzoate

2,6-difluorobenzoic acid

Downstream raw materials:

4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide

C₁₅H₁₀F₂N₂O₂

N-(2-butoxyethyl)-2,6-difluorobenzamide

N-(2-tert-butoxyethyl)-2,6-difluorobenzamide