(3R,4R)-3,4-Difluoropyrrolidin-1-ylethanol

Base Information

• Chemical Name: (3R,4R)-3,4-Difluoropyrrolidin-1-ylethanol
• CAS No.: 871822-43-4
• Molecular Formula: C₆H₁₁F₂NO
• Molecular Weight: 151.156
• Mol file: 871822-43-4.mol

Synonyms:(3R,4R)-3,4-Difluoro-1-pyrrolidineethanol

Chemical Property of (3R,4R)-3,4-Difluoropyrrolidin-1-ylethanol

Chemical Property:

• Boiling Point: 207 ºC
• Flash Point: 79 ºC
• PSA: 23.47000
• Density: 1.20
• LogP: 0.25440

Purity/Quality:

97% ^*data from raw suppliers

(3R,4R)-1-(2-HYDROXYETHYL)-3,4-DIFLUOROPYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3R,4R)-3,4-Difluoropyrrolidin-1-ylethanol

There total 3 articles about (3R,4R)-3,4-Difluoropyrrolidin-1-ylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(3R,4R)-1-(2-benzyloxyethyl)-3,4-difluoropyrrolidine (871822-42-3) → (3R,4R)-1-(2-hydroxyethyl)-3,4-difluoropyrrolidine (871822-43-4)

Guidance literature:

With dimethylsulfide; boron trichloride; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jo0513414

Reference yield:

(3S,4S)-1-(2-benzyloxyethyl)pyrrolidine-3,4-diol → (3R,4R)-1-(2-hydroxyethyl)-3,4-difluoropyrrolidine (871822-43-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 42 percent / triethylamine / CH₂Cl₂ / 16 h / 20 °C

2: 52 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / 20 °C

3: 66 percent / boron trichloride/dimethyl sulfide complex / CH₂Cl₂ / 4 h / 20 °C

With dimethylsulfide; tetrabutyl ammonium fluoride; boron trichloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0513414

Reference yield:

(3S,4S)-1-(2-benzyloxyethyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine (871822-39-8) → (3R,4R)-1-(2-hydroxyethyl)-3,4-difluoropyrrolidine (871822-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / 20 °C

2: 66 percent / boron trichloride/dimethyl sulfide complex / CH₂Cl₂ / 4 h / 20 °C

With dimethylsulfide; tetrabutyl ammonium fluoride; boron trichloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo0513414

upstream raw materials:

(3R,4R)-1-(2-benzyloxyethyl)-3,4-difluoropyrrolidine

(3S,4S)-1-(2-benzyloxyethyl)-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine